Post-operative recurrence and metastasis is a major challenge for breast cancer treatment. Local chemotherapy is a promising strategy that can overcome this problem. In this study, we synthesized an injectable hyaluronic acid (HA)-based hydrogel loaded with paclitaxel (PTX) nanoparticles and epirubicin (EPB) (PPNPs/EPB@HA-Gel). PPNPs/EPB@HA-Gel steadily released the encapsulated drugs to achieve long-term inhibition of tumor recurrence and metastasis in a murine post-operative breast tumor model, which prolonged their survival without any systemic toxicity. The drug-loaded hydrogel inhibited the proliferation and migration of tumor cells in vitro, and significantly increased tumor cell apoptosis in vivo. Therefore, PPNPs/EPB@HA-Gel can be used as a local chemotherapeutic agent to prevent postoperative recurrence and metastasis of breast cancer.

术后复发和转移是乳腺癌治疗的一大挑战。局部化疗是一种很有前景的策略，可以克服这个问题。在这项研究中，我们合成了一种基于可注射透明质酸 (HA) 的水凝胶，其负载有紫杉醇 (PTX) 纳米颗粒和表柔比星 (EPB) (PPNPs/EPB@HA-Gel)。PPNPs/EPB@HA-Gel 稳定释放包封的药物，在小鼠术后乳腺肿瘤模型中实现长期抑制肿瘤复发和转移，延长了它们的生存期，没有任何全身毒性。载药水凝胶体外抑制肿瘤细胞增殖和迁移，体内显着增加肿瘤细胞凋亡。. 因此，PPNPs/EPB@HA-Gel可作为局部化疗药物，预防乳腺癌术后复发和转移。