Background: There has been no investigation so far on the prevalence or causes of hypereosinophilia during rheumatic diseases. Objectives: The study aimed to identify the prevalence and causes of hypereosinophilia among the patients followed in a rheumatology department. Methods: The patients aged 18 years or over followed in our rheumatology department between January 2010 and December 2019 who had at least one AEC ≥1,500/µL measurement in their peripheral blood count were identified retrospectively. Results: Over the 10 years, a total of 130,769 peripheral blood counts were performed, of which 3.9% showed eosinophilia and 0.065% showed hypereosinophilia. Hypereosinophilia was identified in 85 patients. The underlying rheumatic disease was determined in 89.4% (n = 76) of patients. Of these, the most frequent one was rheumatoid arthritis at a ratio of 40.8%, followed by eosinophilic granulomatosis with polyangiitis (EGPA) at a ratio of 10.5%. Hypereosinophilia was in primary form in 3.5% of the patients, whereas secondary to another condition in 91.8% (n = 78) of the cases and idiopathic in 4.7% (n = 4) of patients. The most common cause of secondary hypereosinophilia was drug induced, as detected in 61.2%, followed by allergic conditions in 11.5% and EGPA in 9.4%. In 15.2% (n = 13) of the cases, hypereosinophilia was associated with an underlying rheumatic disease. In the cases with drug-induced hypereosinophilia, most often (in 28.8%) methotrexate was the offending agent. Conclusions: Rheumatologists should be cognizant that hypereosinophilia concurrent to rheumatic diseases is usually not due to the underlying rheumatic disease, except for the conventional eosinophil-related rheumatic diseases.
Int Arch Allergy Immunol

中文翻译：

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风湿病学实践中嗜酸性粒细胞增多症的评估和鉴别诊断

背景：到目前为止，还没有关于风湿性疾病期间嗜酸性粒细胞增多症的患病率或原因的调查。目的：本研究旨在确定风湿病科随访患者中嗜酸性粒细胞增多症的患病率和原因。方法：回顾性确定 2010 年 1 月至 2019 年 12 月在我们风湿科随访的 18 岁或以上的患者，他们的外周血计数至少有一次 AEC ≥1,500/µL 测量值。结果：10 年来，共进行了 130,769 次外周血计数，其中 3.9% 显示嗜酸性粒细胞增多，0.065% 显示嗜酸性粒细胞增多。在 85 名患者中发现了高嗜酸性粒细胞增多症。89.4% ( n = 76) 的患者确定了潜在的风湿病。其中，最常见的是类风湿性关节炎，比例为 40.8%，其次是嗜酸性肉芽肿伴多血管炎 (EGPA)，比例为 10.5%。3.5% 的患者原发性嗜酸性粒细胞增多症，而 91.8% ( n = 78) 的病例继发于另一种疾病，4.7% ( n= 4) 的患者。继发性嗜酸性粒细胞增多最常见的原因是药物引起的，占 61.2%，其次是过敏性疾病，占 11.5%，EGPA 占 9.4%。在 15.2% ( n = 13) 的病例中，嗜酸性粒细胞增多症与潜在的风湿性疾病有关。在药物引起的嗜酸性粒细胞增多症的病例中，最常见的（28.8%）甲氨蝶呤是致病剂。结论：风湿病学家应认识到，除了常规的嗜酸性粒细胞相关风湿性疾病外，风湿性疾病并发嗜酸性粒细胞增多症通常不是由潜在的风湿性疾病引起的。
Int Arch 过敏免疫