Background

Human leukocyte antigen (HLA) plays an important role in immune responses to infections, especially in the development of acquired immunity. Given the high degree of polymorphisms that HLA molecules present, some will be more or less effective in controlling SARS-CoV-2 infection. We wanted to analyze whether certain polymorphisms may be involved in the protection or susceptibility to COVID-19.

Methods

We studied the polymorphisms in HLA class I (HLA-A, -B and -C) and II (HLA-DRB1 and HLA-DQB1) molecules in 450 patients who required hospitalization for COVID-19, creating one of the largest HLA-typed patient cohort to date.

Results

Our results show that there is no relationship between HLA polymorphisms or haplotypes and susceptibility or protection to COVID-19.

Conclusion

Our results may contribute to resolve the contradictory data on the role of HLA polymorphisms in COVID-19 infection.

人类白细胞抗原 (HLA) 在对感染的免疫反应中起着重要作用，尤其是在获得性免疫的发展中。鉴于 HLA 分子存在的高度多态性，一些在控制 SARS-CoV-2 感染方面或多或少会有效。我们想分析某些多态性是否可能与 COVID-19 的保护或易感性有关。为此，我们研究了 450 名因 COVID-19 而需要住院治疗的患者的 HLA I 类（HLA-A、-B 和 -C）和 II 类（HLA-DRB1 和 HLA-DQB1）分子的多态性，创建了其中一个迄今为止最大的 HLA 型患者队列。我们的结果表明，HLA 多态性或单倍型与对 COVID-19 的易感性或保护性之间没有关系。