Purpose

This paper aims to propose a suitable atomizing solidification chitosan (CS) gel liquid extrusion molding technology for the three dimensional (3D) printing method, and experiments verify the feasibility of this method.

Design/methodology/approach

This paper mainly uses experimental means, combined with theoretical research. The preparation method, solidification forming method and 3D printing method of CS gel solution were studied. The CS gel printing mechanism and printing error sources are analyzed on the basis of the CS gel ink printing results, printing performance with different ratios of components by constructing a gel print prototype, experiments evaluating the CS gel printing technology and the effects of the process parameters on the scaffold formation.

Findings

CS printing ink was prepared; the optimal formula was found; the 3 D printing experiment of CS was completed; the optimal printing parameters were obtained; and the reliability of the forming prototype, printing ink and gel printing process was verified, which allowed for the possibility to apply the 3 D printing technology to the manufacturing of a CS gel structure.

Originality/value

This study can provide theoretical and technical support for the potential application of CS 3 D printed gels in tissue engineering.

中文翻译：

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雾化凝固液体辅助挤出成型壳聚糖凝胶3D打印技术及实验研究

目的

本文旨在提出一种适用于三维（3D）打印方法的雾化固化壳聚糖（CS）凝胶液体挤出成型技术，并通过实验验证了该方法的可行性。

设计/方法/方法

本文主要采用实验手段，结合理论研究。研究了CS凝胶溶液的制备方法、固化成型方法和3D打印方法。从CS凝胶油墨印刷结果、构建凝胶印刷原型的不同组分比例的印刷性能、CS凝胶印刷技术评价实验和工艺参数影响等方面分析了CS凝胶印刷机理和印刷误差来源。在脚手架的形成上。

发现

制备CS油墨；找到了最佳公式；完成CS的3D打印实验；得到最佳印刷参数；并验证了成型原型、印刷油墨和凝胶打印过程的可靠性，这为将 3D 打印技术应用于 CS 凝胶结构的制造提供了可能。

原创性/价值

该研究可为CS 3D打印凝胶在组织工程中的潜在应用提供理论和技术支持。