In the paper by Sze and Brunton, entitled ‘Effects of prenatal stress on neuroactive steroid responses to acute stress in adult male and female rats’ (J Neuroendocrinol. 2021;33:e12916),1 panel H in Figure 9 was incorrect. The correct figure is as follow:
FIGURE 9
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Allopregnanolone concentrations in the plasma and brain regions of male and female control (Con) and prenatally stressed (PNS) offspring. In males, a significant main effect of acute stress was observed for the plasma and all brain regions, where the swim-stressed rats had greater concentrations of allopregnanolone in the circulation and brain compared to the basal groups, under both control and PNS conditions (*P < 0.05; **P < 0.01; ***P < 0.001). No main effects of prenatal stress were observed in the male plasma or in any of the brain regions. In females, there was no effect of prenatal stress or acute stress on plasma allopregnanolone concentrations. In the brain, no effect of prenatal stress was observed. A main effect of acute stress was observed in the frontal cortex (D), hypothalamus (F) and brainstem (L) of the females; however, post-hoc testing revealed significant group differences only in the frontal cortex (D) and hypothalamus (F), where PNS, but not control, swim-stressed rats had greater concentrations of allopregnanolone compared to their respective basal group (*P < 0.05). Note the difference in the scale of the y axes between the sexes. NS, not significant. n = 9 or 10 rats per group
Correspondingly, under section 3.4 Progesterone, DHP and allopregnanolone, the last paragraph on page 12 should not refer to the amygdala in Figure 9(H). The correct sentence should be:
In females, there were main effects of acute stress in most brain regions for progesterone (Figure 7), although only in the frontal cortex for DHP (Figure 8D), and the frontal cortex (Figure 9D), hypothalamus (Figure 9F) and brainstem (Figure 9L) for allopregnanolone.
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