C4’-Fluorinated Oligodeoxynucleotides: Synthesis, Stability, Structural Studies,Chemistry - A European Journal

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C4’-Fluorinated Oligodeoxynucleotides: Synthesis, Stability, Structural Studies
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2021-08-25 , DOI: 10.1002/chem.202102561
Yifei Zhou ₁ , Kuan Lu ₁ , Qiang Li ₁ , Chaochao Fan ₁ , Chuanzheng Zhou ₁

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4’-F-Thymidine was synthesized and introduced into DNA strands based on standard solid-phase DNA synthesis protocols. The 4’-F-thymidine in the context of DNA strand is rather stable in neutral buffers. Unlike native deoxyribonucleosides whose ribose predominantly exist in the South conformation, 4’-F-thymidine prefers the North conformation. Incorporation of 4’-F-deoxyribonucleoside into nucleic acids represents an advanced approach to modulate the local structure and, hence, the function of nucleic acids.

中文翻译：

C4'-氟化寡脱氧核苷酸：合成、稳定性、结构研究

4'-F-胸苷是根据标准固相 DNA 合成方案合成并引入 DNA 链的。DNA 链中的 4'-F-胸苷在中性缓冲液中相当稳定。与核糖主要存在于南构象的天然脱氧核糖核苷不同，4'-F-胸苷更喜欢北构象。将 4'-F-脱氧核糖核苷掺入核酸代表了一种先进的方法来调节局部结构，从而调节核酸的功能。

更新日期：2021-10-25

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