Cerebral specialization and inter-hemispheric cooperation are two of the most prominent functional architectures of the human brain. Their dysfunctions may be related to pathophysiological changes in patients with Parkinson’s disease (PD), who are characterized by unbalanced onset and progression of motor symptoms. This study aimed to characterize the two intrinsic architectures of hemispheric functions in PD using resting-state functional magnetic resonance imaging. Seventy idiopathic PD patients and 70 age-, sex-, and education-matched healthy subjects were recruited. All participants underwent magnetic resonance image scanning and clinical evaluations. The cerebral specialization (Autonomy index, AI) and inter-hemispheric cooperation (Connectivity between Functionally Homotopic voxels, CFH) were calculated and compared between groups. Compared with healthy controls, PD patients showed stronger AI in the left angular gyrus. Specifically, this difference in specialization resulted from increased functional connectivity (FC) of the ipsilateral areas (e.g., the left prefrontal area), and decreased FC in the contralateral area (e.g., the right supramarginal gyrus). Imaging-cognitive correlation analysis indicated that these connectivity were positively related to the score of Montreal Cognitive Assessment in PD patients. CFH between the bilateral sensorimotor regions was significantly decreased in PD patients compared with controls. No significant correlation between CFH and cognitive scores was found in PD patients. This study illustrated a strong leftward specialization but weak inter-hemispheric coordination in PD patients. It provided new insights to further clarify the pathological mechanism of PD.

大脑专业化和半球间合作是人类大脑最突出的两个功能架构。它们的功能障碍可能与帕金森病 (PD) 患者的病理生理变化有关，其特征是运动症状的不平衡发作和进展。本研究旨在使用静息状态功能磁共振成像来表征 PD 半球功能的两种内在结​​构。招募了 70 名特发性 PD 患者和 70 名年龄、性别和教育匹配的健康受试者。所有参与者都接受了磁共振图像扫描和临床评估。计算并比较组间的大脑专业化（自主指数，AI）和半球间合作（功能同位体素之间的连接，CFH）。与健康对照组相比，PD 患者的左角回表现出更强的 AI。具体而言，这种专业化差异是由于同侧区域（例如，左侧前额区域）的功能连接性（FC）增加，而对侧区域（例如，右侧缘上回）的功能连接性（FC）降低。影像-认知相关分析表明，这些连通性与 PD 患者的蒙特利尔认知评估得分呈正相关。与对照组相比，PD 患者双侧感觉运动区域之间的 CFH 显着降低。在 PD 患者中未发现 CFH 与认知评分之间存在显着相关性。该研究表明 PD 患者具有强烈的左倾特化但大脑半球间的协调性较弱。