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The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4+ T Cells via a Novel CDK8-GATA3-FOXP3 Pathway
Molecular and Cellular Biology ( IF 3.2 ) Pub Date : 2021-08-24 , DOI: 10.1128/mcb.00085-21 Azlann Arnett 1 , Keagan G Moo 1 , Kaitlin J Flynn 1 , Thomas B Sundberg 2 , Liv Johannessen 3 , Alykhan F Shamji 2 , Nathanael S Gray 3 , Thomas Decker 4 , Ye Zheng 5 , Vivian H Gersuk 1 , Ziaur S Rahman 6 , David E Levy 7 , Isabelle J Marié 7 , Peter S Linsley 1 , Ramnik J Xavier 8, 9 , Bernard Khor 1
Molecular and Cellular Biology ( IF 3.2 ) Pub Date : 2021-08-24 , DOI: 10.1128/mcb.00085-21 Azlann Arnett 1 , Keagan G Moo 1 , Kaitlin J Flynn 1 , Thomas B Sundberg 2 , Liv Johannessen 3 , Alykhan F Shamji 2 , Nathanael S Gray 3 , Thomas Decker 4 , Ye Zheng 5 , Vivian H Gersuk 1 , Ziaur S Rahman 6 , David E Levy 7 , Isabelle J Marié 7 , Peter S Linsley 1 , Ramnik J Xavier 8, 9 , Bernard Khor 1
Affiliation
Immune health requires innate and adaptive immune cells to engage precisely balanced
pro- and anti-inflammatory forces. We employ the concept of chemical immunophenotypes
to classify small molecules functionally or mechanistically according to their ...
中文翻译：
细胞周期蛋白依赖性激酶 8 (CDK8) 抑制剂 DCA 通过新型 CDK8-GATA3-FOXP3 途径促进 CD4+ T 细胞产生耐受性化学免疫表型
免疫健康需要先天性和适应性免疫细胞来精确平衡促炎和抗炎力量。我们采用化学免疫表型的概念，根据小分子的功能或机制对它们进行分类……
更新日期：2021-09-12
中文翻译：
细胞周期蛋白依赖性激酶 8 (CDK8) 抑制剂 DCA 通过新型 CDK8-GATA3-FOXP3 途径促进 CD4+ T 细胞产生耐受性化学免疫表型
免疫健康需要先天性和适应性免疫细胞来精确平衡促炎和抗炎力量。我们采用化学免疫表型的概念，根据小分子的功能或机制对它们进行分类……
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