Comparative life cycle assessment of NAD(P)H regeneration technologies,Green Chemistry

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Comparative life cycle assessment of NAD(P)H regeneration technologies
Green Chemistry ( IF 9.3 ) Pub Date : 2021-08-17 , DOI: 10.1039/d1gc02349g
Joseph W. H. Burnett _{1,

2} , Ziying Sun ₃ , Jianwei Li ₁ , Xiaonan Wang ₃ , Xiaodong Wang ₁

Affiliation

NAD(P)H is a key cofactor widely used in biocatalytic reductive transformations, facilitating a wide range of industrially significant reactions which ultimately result in the consumption of the costly cofactor. To make NAD(P)H dependent biotransformations sustainable and economically feasible, different catalytic routes have been investigated to regenerate NAD(P)H. Here we report a comprehensive life cycle assessment (LCA) of these catalytic regeneration methods. Midpoint characterisation and normalisation show that the synthesis of the catalyst, specifically the use of noble metals and energy consumption, dominate the environmental impacts and have the greatest contribution to all considered impact categories. This comparative LCA highlights the need for future investigation into noble metal based catalyst alternatives, to provide cleaner and more sustainable methods of regenerating the cofactor NAD(P)H.

中文翻译：

NAD(P)H再生技术的生命周期比较评估

NAD(P)H 是一种广泛用于生物催化还原转化的关键辅因子，可促进各种具有工业意义的反应，最终导致昂贵的辅因子的消耗。为了使 NAD(P)H 依赖的生物转化可持续和经济可行，已经研究了不同的催化路线来再生 NAD(P)H。在这里，我们报告了这些催化再生方法的综合生命周期评估 (LCA)。中点表征和归一化表明，催化剂的合成，特别是贵金属的使用和能源消耗，在环境影响中占主导地位，并对所有考虑的影响类别贡献最大。这种比较 LCA 强调了未来研究贵金属基催化剂替代品的必要性，

更新日期：2021-08-24

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