Dermatophagoides pteronyssinus (DPT) is the most common source of indoor airborne allergens worldwide. To date, 30 allergens have been described, with Der p 1 and Der p 2 being the most relevant in mite respiratory allergies¹. In recent years, Der p 23, a peritrophin-like protein that is mainly present in the posterior midgut and the outer membrane of mite faeces, has also been identified as a potent allergen, despite its low concentrations^1,2. Previous studies have demonstrated that Der p 23 elicits a positive sensitisation rate of 75% in patients with house dust mite (HDM) allergies, particularly in children with persistent moderate-to-severe asthma^2-5. Different studies have investigated the correlation between the levels of HDM allergen exposure and risk of developing allergic sensitisation and, consequently, allergic symptoms^3,6. However, the levels of Der p 23 to which patients are environmentally exposed remain unknown. Therefore, the aim of this study was to quantify the Der p 23 levels in household dust samples and to investigate the correlations with Der p 1 and Der p 2 levels and the number of adult mites.

中文翻译：

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家庭灰尘样品中 Der p 23 的环境暴露

屋尘螨(DPT) 是全球最常见的室内空气传播过敏原来源。迄今为止，已经描述了 30 种过敏原，其中 Der p 1 和 Der p 2 与螨呼吸道过敏¹最相关。近年来，Der p 23 是一种主要存在于后中肠和螨粪便外膜中的类 peritrophin 蛋白，尽管其浓度较低^1,2 ，但它也被确定为一种强效过敏原。先前的研究表明，Der p 23 在屋尘螨 (HDM) 过敏患者中引起 75% 的阳性致敏率，特别是在患有持续中度至重度哮喘的儿童中^2-5. 不同的研究调查了 HDM 过敏原暴露水平与发生过敏性致敏的风险以及因此过敏症状^3,6之间的相关性。然而，患者暴露于环境中的 Der p 23 水平仍然未知。因此，本研究的目的是量化家庭灰尘样本中的 Der p 23 水平，并研究 Der p 1 和 Der p 2 水平与成螨数量的相关性。