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Assessment of event-related evoked potentials and China-Wechsler intelligence scale for cognitive dysfunction in children with obstructive sleep apnea
International Journal of Pediatric Otorhinolaryngology ( IF 1.2 ) Pub Date : 2021-08-24 , DOI: 10.1016/j.ijporl.2021.110901
Yewen Shi 1 , Yani Feng 1 , Yitong Zhang 1 , Haiqin Liu 1 , Huanan Luo 1 , Lei Shang 2 , Liang Xing 3 , Jin Hou 1 , Jing Yan 1 , Xiaohong Liu 1 , Qingqing Zhang 1 , Chao Si 1 , Xiaoyong Ren 1
Affiliation  

Objective

To explore the relationship between obstructive sleep apnea (OSA) and cognitive impairment by combining event-related evoked potentials (ERPs) and China-Wechsler Younger Children Scale (C-WISC) in children with sleep-disordered breathing (SDB) with vs. without OSA.

Methods

This was a retrospective case-control study of all consecutive children (n = 148) with adenoid tonsil hypertrophy between July 2017 and March 2019 at the Hospital.

Results

The children were divided into the OSA (n = 102) and non-OSA (n = 46) groups. The apnea-hypopnea index (AHI), obstructive apnea index (OAI), and obstructive apnea-hypopnea index (OAHI) in the OSA group were elevated compared with those of the non-OSA group (all P < 0.001). The mean oxygen saturation (SaO2) and SaO2 nadir were lower in the OSA group compared with the non-OSA group (both P < 0.001). The respiratory arousal index (RAI) values in the OSA group were larger than those of the non-OSA group (P < 0.001). The P300 and N100 latencies in the OSA group were longer than those of the non-OSA group (both P < 0.001). Pearson's correlation analysis revealed correlations of the P300 peak latency with full-scale intelligence quotient (FIQ) (P < 0.001 and r = −0.527), verbal intelligence quotient (VIQ) (P < 0.001 and r = −0.448), and performance intelligence quotient (PIQ) (P < 0.001 and r = −0.515). There was a correlation between the N100 peak latency and PIQ (P = 0.026 and r = −0.183).

Conclusion

ERPs, as an objective measurement, might help assess cognitive impairment in children with OSA.



中文翻译:

阻塞性睡眠呼吸暂停患儿认知功能障碍事件相关诱发电位及China-Wechsler智力量表评估

客观的

结合事件相关诱发电位(ERPs)和China-Wechsler Younger Children Scale(C-WISC)对睡眠呼吸障碍(SDB)患儿进行对比分析,探讨阻塞性睡眠呼吸暂停(OSA)与认知障碍的关系安全局。

方法

这是一项回顾性病例对照研究,对 2017 年 7 月至 2019 年 3 月期间在医院所有连续患有腺样体扁桃体肥大的儿童(n = 148)进行了回顾性病例对照研究。

结果

儿童被分为 OSA (n = 102) 和非 OSA (n = 46) 组。OSA组的呼吸暂停低通气指数(AHI)、阻塞性呼吸暂停指数(OAI)和阻塞性呼吸暂停低通气指数(OAHI)较非OSA组升高(均P < 0.001)。平均氧饱和度 (SaO 2 ) 和 SaO 2与非 OSA 组相比,OSA 组的最低点较低(均 P < 0.001)。OSA 组的呼吸觉醒指数(RAI)值大于非 OSA 组(P < 0.001)。OSA 组的 P300 和 N100 潜伏期长于非 OSA 组(均 P < 0.001)。Pearson 的相关分析揭示了 P300 峰值延迟与全面智商 (FIQ)(P < 0.001 和 r = -0.527)、言语智商(VIQ)(P < 0.001 和 r = -0.448)和表现智力的相关性商 (PIQ)(P < 0.001 和 r = -0.515)。N100 峰值潜伏期与 PIQ 之间存在相关性(P = 0.026 和 r = -0.183)。

结论

作为一种客观测量,ERP 可能有助于评估 OSA 儿童的认知障碍。

更新日期:2021-08-25
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