Assessment of event-related evoked potentials and China-Wechsler intelligence scale for cognitive dysfunction in children with obstructive sleep apnea,International Journal of Pediatric Otorhinolaryngology

当前位置： X-MOL 学术 › Int. J. Pediatr. Otorhinolaryngol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Assessment of event-related evoked potentials and China-Wechsler intelligence scale for cognitive dysfunction in children with obstructive sleep apnea
International Journal of Pediatric Otorhinolaryngology ( IF 1.2 ) Pub Date : 2021-08-24 , DOI: 10.1016/j.ijporl.2021.110901
Yewen Shi ₁ , Yani Feng ₁ , Yitong Zhang ₁ , Haiqin Liu ₁ , Huanan Luo ₁ , Lei Shang ₂ , Liang Xing ₃ , Jin Hou ₁ , Jing Yan ₁ , Xiaohong Liu ₁ , Qingqing Zhang ₁ , Chao Si ₁ , Xiaoyong Ren ₁

Affiliation

Objective

To explore the relationship between obstructive sleep apnea (OSA) and cognitive impairment by combining event-related evoked potentials (ERPs) and China-Wechsler Younger Children Scale (C-WISC) in children with sleep-disordered breathing (SDB) with vs. without OSA.

Methods

This was a retrospective case-control study of all consecutive children (n = 148) with adenoid tonsil hypertrophy between July 2017 and March 2019 at the Hospital.

Results

The children were divided into the OSA (n = 102) and non-OSA (n = 46) groups. The apnea-hypopnea index (AHI), obstructive apnea index (OAI), and obstructive apnea-hypopnea index (OAHI) in the OSA group were elevated compared with those of the non-OSA group (all P < 0.001). The mean oxygen saturation (SaO₂) and SaO₂ nadir were lower in the OSA group compared with the non-OSA group (both P < 0.001). The respiratory arousal index (RAI) values in the OSA group were larger than those of the non-OSA group (P < 0.001). The P300 and N100 latencies in the OSA group were longer than those of the non-OSA group (both P < 0.001). Pearson's correlation analysis revealed correlations of the P300 peak latency with full-scale intelligence quotient (FIQ) (P < 0.001 and r = −0.527), verbal intelligence quotient (VIQ) (P < 0.001 and r = −0.448), and performance intelligence quotient (PIQ) (P < 0.001 and r = −0.515). There was a correlation between the N100 peak latency and PIQ (P = 0.026 and r = −0.183).

Conclusion

ERPs, as an objective measurement, might help assess cognitive impairment in children with OSA.

中文翻译：

阻塞性睡眠呼吸暂停患儿认知功能障碍事件相关诱发电位及China-Wechsler智力量表评估

客观的

结合事件相关诱发电位（ERPs）和China-Wechsler Younger Children Scale（C-WISC）对睡眠呼吸障碍（SDB）患儿进行对比分析，探讨阻塞性睡眠呼吸暂停（OSA）与认知障碍的关系安全局。

方法

这是一项回顾性病例对照研究，对 2017 年 7 月至 2019 年 3 月期间在医院所有连续患有腺样体扁桃体肥大的儿童（n = 148）进行了回顾性病例对照研究。

结果

儿童被分为 OSA (n = 102) 和非 OSA (n = 46) 组。OSA组的呼吸暂停低通气指数（AHI）、阻塞性呼吸暂停指数（OAI）和阻塞性呼吸暂停低通气指数（OAHI）较非OSA组升高（均P < 0.001）。平均氧饱和度 (SaO ₂ ) 和 SaO ₂与非 OSA 组相比，OSA 组的最低点较低（均 P < 0.001）。OSA 组的呼吸觉醒指数（RAI）值大于非 OSA 组（P < 0.001）。OSA 组的 P300 和 N100 潜伏期长于非 OSA 组（均 P < 0.001）。Pearson 的相关分析揭示了 P300 峰值延迟与全面智商 (FIQ)（P < 0.001 和 r = -0.527）、言语智商（VIQ）（P < 0.001 和 r = -0.448）和表现智力的相关性商 (PIQ)（P < 0.001 和 r = -0.515）。N100 峰值潜伏期与 PIQ 之间存在相关性（P = 0.026 和 r = -0.183）。