Purpose: In our study, we aimed to determine the frequency of thyroid nodules in patients with acromegaly according to the American College of Radiology (ACR) Thyroid Imaging, Reporting and Data System (TI-RADS) classification and its relationship with acromegaly disease activity. Methods: A total of 56 patients with acromegaly and age, sex, and body mass index matched with 56 healthy control subjects were included in our study. Thyroid-stimulating hormone, free thyroxine, and anti-thyroperoxidase antibody levels of patients and control subjects were measured. In addition, patients and healthy controls were evaluated by ultrasonography to determine thyroid structure, thyroid volume, and thyroid nodules and to make ACR TI-RADS classification. Results: Thyroid nodules were present in 31 (55.4%) of 56 patients in the acromegaly group and 20 (35.7%) of 56 subjects in the control group, and the frequency of thyroid nodules was significantly higher in the acromegaly group (p=0.038). The mean number of nodules in the acromegaly group and control group was 1.27±1.43 and 0.48±0.73, respectively, and the mean number of nodules was significantly higher in the acromegaly group (p=0.003). The number of patients with TI-RADS 1, TI-RADS 2, and TI-RADS 4 nodules in the acromegaly group was higher than the control group (p=0.026, p=0.049, p=0.007, respectively). No difference was found in terms of cytological findings between those who have undergone FNAB in the acromegaly group and control group. Conclusion: In our study, we found that the frequency of thyroid nodules, the number of thyroid nodules, and the number of TI-RADS 1, TI-RADS 2, and TI-RADS 4 nodules increased in patients with acromegaly. There was no significant difference between acromegaly disease activity and thyroid nodule frequency, number of thyroid nodules, and TI-RADS classifications.

中文翻译：

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肢端肥大症患者的甲状腺结节：根据 ACR TI-RADS 分类的频率及其与疾病活动的关系

目的：在我们的研究中，我们旨在根据美国放射学会 (ACR) 甲状腺成像、报告和数据系统 (TI-RADS) 分类及其与肢端肥大症疾病活动的关系来确定肢端肥大症患者甲状腺结节的频率。方法：本研究共纳入 56 名肢端肥大症患者，年龄、性别、体重指数与 56 名健康对照者相匹配。测量患者和对照受试者的促甲状腺激素、游离甲状腺素和抗甲状腺过氧化物酶抗体水平。此外，通过超声检查评估患者和健康对照，以确定甲状腺结构、甲状腺体积和甲状腺结节，并进行 ACR TI-RADS 分类。结果：肢端肥大症组 56 名患者中有 31 名（55.4%）和 20 名（35. 7%)，对照组 56 名受试者的甲状腺结节发生率明显高于肢端肥大症组 (p=0.038)。肢端肥大症组和对照组的平均结节数分别为 1.27±1.43 和 0.48±0.73，肢端肥大症组的平均结节数明显更高（p=0.003）。肢端肥大症组出现 TI-RADS 1、TI-RADS 2 和 TI-RADS 4 结节的患者数量高于对照组（分别为 p=0.026、p=0.049、p=0.007）。肢端肥大症组和对照组接受 FNAB 的患者在细胞学检查方面没有发现差异。结论：在我们的研究中，我们发现肢端肥大症患者甲状腺结节的频率、甲状腺结节的数量以及 TI-RADS 1、TI-RADS 2 和 TI-RADS 4 结节的数量增加。