A reusable and recoverable PEG-supported hypervalent iodine reagent is reported. This hypervalent iodine reagent, immobilized in a soluble polymer support, was easily prepared in six steps from PEG-OH 2000. This reagent was successfully applied in a mild sulfonamide synthesis using a sulfinate salt and an amine in up to 95% yield. The use of the soluble polymer allowed a facile workup procedure and reaction monitoring, by simple precipitation and filtration of the reagent, with an easy recovery and subsequent re-oxidation and reuse. This approach greatly improves the sustainability of this sulfonamide synthesis method, avoiding frequent preparation of reagents and generation of waste during the purification steps.

报道了一种可重复使用和可回收的 PEG 支持的高价碘试剂。这种固定在可溶性聚合物载体中的高价碘试剂可以通过 PEG-OH 2000 的六个步骤轻松制备。该试剂成功应用于使用亚磺酸盐和胺的温和磺酰胺合成，产率高达 95%。可溶性聚合物的使用允许通过简单的试剂沉淀和过滤、易于回收和随后的再氧化和再利用进行简便的后处理程序和反应监测。这种方法大大提高了这种磺胺合成方法的可持续性，避免了在纯化步骤中频繁制备试剂和产生废物。