miRNAs play a crucial part in multiple biological processes of cell proliferation, migration, apoptosis, and chemoresistance. In cancer, miRNAs can be divided into oncogenes or tumor suppressors on the basis of their functions in the carcinogenic process. The purpose of this study was to explore the roles and clinical diagnostic value of miR-370-3p in breast cancer. Our results demonstrated that miR-370-3p significantly promoted proliferation, metastasis, and stemness of breast cancer in vitro and in vivo. In particular, clinical data revealed that high expression of serum miR-370-3p and exosomal miR-370-3p from breast cancer patients was remarkably correlated with lymphatic metastasis and tumor node metastasis (TNM) stages. Mechanistically, miR-370-3p inhibited FBLN5 expression and activated the NF-κB signaling pathway to promote breast cancer cell proliferation, migration, and stemness. FBLN5 expression was significantly decreased in breast cancer cells and tumor tissues of breast cancer patients. Our research identified that miR-370-3p promoted breast cancer progression by inhibiting FBLN5 expression and activating the NF-κB signaling pathway. Serum exosomal miR-370-3p would provide a potential biomarker for the diagnosis of breast cancer.

中文翻译：

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miR-370-3p 作为新型生物标志物通过靶向 FBLN5 促进乳腺癌进展

miRNAs 在细胞增殖、迁移、凋亡和化学抗性等多种生物学过程中起着至关重要的作用。在癌症中，miRNA根据其在致癌过程中的功能可分为致癌基因或抑癌基因。本研究的目的是探讨miR-370-3p在乳腺癌中的作用和临床诊断价值。我们的研究结果表明，miR-370-3p在体外和体内均显着促进了乳腺癌的增殖、转移和干性. 特别是，临床数据显示，乳腺癌患者血清 miR-370-3p 和外泌体 miR-370-3p 的高表达与淋巴转移和肿瘤淋巴结转移 (TNM) 分期显着相关。在机制上，的miR-370-3p抑制FBLN5表达和活化的NF-的κ乙信号通路以促进乳腺癌细胞增殖，迁移，和干性。FBLN5在乳腺癌细胞和乳腺癌患者肿瘤组织中的表达显着降低。我们的研究确定了miR-370-3p通过抑制FBLN5表达和激活NF-促进乳腺癌发展κ乙信号传导途径。血清外泌体 miR-370-3p 将为乳腺癌的诊断提供潜在的生物标志物。