To establish infection, enteric pathogens integrate environmental cues to navigate the gastrointestinal tract and precisely control expression of virulence determinants. Emerging data indicate that post-transcriptional and post-translational gene regulation plays a key role in virulence regulation and pathogen adaptation to the host environment. Here, we highlight recent studies that reveal how physiologically relevant signals initiate post-transcriptional and post-translational regulatory circuits and the impact on virulence gene expression in the attaching and effacing pathogens, enteropathogenic Escherichia coli, enterohemorrhagic E. coli O157:H7, and Citrobacter rodentium.

为了建立感染，肠道病原体整合环境线索来导航胃肠道并精确控制毒力决定因素的表达。新出现的数据表明，转录后和翻译后基因调控在毒力调控和病原体对宿主环境的适应中起关键作用。在这里，我们重点介绍了最近的研究，这些研究揭示了生理相关信号如何启动转录后和翻译后调节回路，以及对附着和消除病原体、肠致病性大肠杆菌、肠出血性大肠杆菌O157:H7 和柠檬酸杆菌中毒力基因表达的影响。啮齿目。