Manipulation of host metabolic fluxes by Leishmania represents a strategy to circumvent host immune response leading to long-term parasite survival and playing an important role in the pathology of infection. Specific Leishmania-dependent metabolic alterations in infected macrophages have been associated with resistance or susceptibility to infection. Thus, deciphering the multilevel interactions between metabolism and function on innate immune cells during infection offers considerable therapeutic or prophylactic promise. In this review, we provide an overview of recent literature highlighting Leishmania-macrophage interactions and discuss the potential of metabolic targeted therapies to shift the balance of dysfunctional, damaging, or non-productive responses to protective immune reactivity patterns towards pathogen elimination.

利什曼原虫对宿主代谢通量的操纵代表了一种规避宿主免疫反应的策略，导致寄生虫长期存活并在感染病理学中发挥重要作用。受感染的巨噬细胞中特定的利什曼原虫依赖性代谢改变与对感染的抵抗力或易感性有关。因此，破译感染期间先天免疫细胞的代谢和功能之间的多层次相互作用提供了相当大的治疗或预防前景。在这篇综述中，我们概述了最近强调利什曼原虫的文献——巨噬细胞相互作用，并讨论代谢靶向疗法的潜力，将功能失调、破坏性或非生产性反应的平衡转变为保护性免疫反应模式，以消除病原体。