Background

Because of cardiac hypertrophy and electrophysiological alterations associated with preeclampsia, worsening of preexisting arrhythmias or occurrence of de novo arrhythmias are common in patients with preeclampsia. Tp-e/QT and Tpe/QTc ratios are accepted as reliable indexes for predicting ventricular arrhythmias. In this study, we examined the impact of preeclampsia on ventricular repolarization indices in patients with preeclampsia by using the QT, QTc and Tp-e interval, Tp-e/QTratio, and Tp-e/QTc ratio.

Methods

We analyzed electrocardiographic recordings of sixty pregnant women with preeclampsia and thirty age-matched healthy pregnant women. Women presenting with preeclampsia were divided into 2 groups and classified as early (gestational age < 34 weeks at clinical onset) or late (≥34 weeks) onset preeclampsia. Ventricular repolarization indices were evaluated.

Results

The QT and Tp-e intervals were found to be longer in patients with earlyonset preeclampsia compared to patients with late-onset preeclampsia and helthy pregnants (377.6 ± 23 ms vs 374.3 ± 15 ms, 362 ± 15 ms & 82.6 ± 9.4 ms vs 74.0 ± 10.6 ms, 68.6 ± 10 ms). In adition, Tp-e/QT and Tp-e/QTc ratio were significantly higher in this patient population compared to others (0.21 ± 0.02 vs 0.19 ± 0.02, 0.18 ± 0.02 & 0.19 ± 0.02 vs 0.16 ± 0.02, 0.15 ± 0,02, p < 0.05 respectively).

Conclusion

Our data showed that preeclampsia has unfavorable effects on electrocardiographic indices of ventricular repolarization compared to healthy pregnant women. This effect is more prominent in patients with early-onset preeclampsia.

中文翻译：

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先兆子痫对心室复极指数的影响

背景

由于先兆子痫相关的心脏肥大和电生理改变，先兆子痫患者常见心律失常恶化或新发心律失常。Tp-e/QT 和 Tpe/QTc 比值被认为是预测室性心律失常的可靠指标。在本研究中，我们通过使用 QT、QTc 和 Tp-e 间期、Tp-e/QTratio 和 Tp-e/QTc 比值来检查先兆子痫对先兆子痫患者心室复极指数的影响。

方法

我们分析了 60 名患有先兆子痫的孕妇和 30 名年龄匹配的健康孕妇的心电图记录。患有先兆子痫的女性被分为两组，分为早期（临床发病胎龄 < 34 周）或晚期（≥ 34 周）先兆子痫。评价心室复极指数。

结果

发现早发性先兆子痫患者的 QT 和 Tp-e 间期比晚发性先兆子痫和健康妊娠患者更长（377.6 ± 23 ms vs 374.3 ± 15 ms, 362 ± 15 ms & 82.6 ± 9.4 ms vs 740。 ± 10.6 毫秒、68.6 ± 10 毫秒）。此外，与其他患者相比，该患者群体中的 Tp-e/QT 和 Tp-e/QTc 比率显着更高（0.21 ± 0.02 vs 0.19 ± 0.02、0.18 ± 0.02 & 0.19 ± 0.02 vs 0.16 ± 0.02、0, 0.15） 02， 分别为p < 0.05）。

结论

我们的数据显示，与健康孕妇相比，先兆子痫对心室复极的心电图指标有不利影响。这种作用在早发性先兆子痫患者中更为突出。