Evaluation of intraosteoblastic activity of dalbavancin against Staphylococcus aureus in an ex vivo model of bone cell infection,Journal of Antimicrobial Chemotherapy

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Evaluation of intraosteoblastic activity of dalbavancin against Staphylococcus aureus in an ex vivo model of bone cell infection
Journal of Antimicrobial Chemotherapy ( IF 3.9 ) Pub Date : 2021-08-23 , DOI: 10.1093/jac/dkab299
Pierre Chauvelot _{1,

2,

3} , Céline Dupieux-Chabert _{1,

2,

4,

5} , Lélia Abad ₁ , Aubin Souche _{1,

2,

4,

5} , Tristan Ferry _{1,

2,

3,

4} , Jérôme Josse _{1,

2,

4} , Frédéric Laurent _{1,

2,

4,

5} , Florent Valour _{1,

2,

3,

4}

Affiliation

Long-acting lipoglycopeptides are promising therapeutic options in Staphylococcus aureus bone and joint infections (BJIs). This study evaluated the ability of dalbavancin to eradicate the intraosteoblastic reservoir of S. aureus, associated with BJI chronicity.

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