Responding to the recent interest of the yeast research community in non-Saccharomyces cerevisiae species of biotechnological relevance, the N.C.Yeastract (http://yeastract-plus.org/ncyeastract/) was associated to YEASTRACT + (http://yeastract-plus.org/). The YEASTRACT + portal is a curated repository of known regulatory associations between transcription factors (TFs) and target genes in yeasts. N.C.Yeastract gathers all published regulatory associations and TF-binding sites for Komagataellaphaffii (formerly Pichia pastoris), the oleaginous yeast Yarrowia lipolytica, the lactose fermenting species Kluyveromyces lactis and Kluyveromyces marxianus, and the remarkably weak acid-tolerant food spoilage yeast Zygosaccharomyces bailii. The objective of this review paper is to advertise the update of the existing information since the release of N.C.Yeastract in 2019, and to raise awareness in the community about its potential to help the day-to-day work on these species, exploring all the information available in the global YEASTRACT + portal. Using simple and widely used examples, a guided exploitation is offered for several tools: (i) inference of orthologous genes; (ii) search for putative TF binding sites and (iii) inter-species comparison of transcription regulatory networks and prediction of TF-regulated networks based on documented regulatory associations available in YEASTRACT + for well-studied species. The usage potentialities of the new CommunityYeastract platform by the yeast community are also discussed.

中文翻译：

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NCYeastract 和 CommunityYeastract 数据库用于研究非常规酵母中的基因和基因组转录调控

为了响应酵母研究界最近对具有生物技术相关性的非酿酒酵母物种的兴趣，NCYeastract (http://yeastract-plus.org/ncyeastract/) 与 YEASTRACT + (http://yeastract-plus.组织/）。YEASTRACT + 门户是酵母中转录因子 (TF) 和靶基因之间已知调控关联的精选存储库。NCYeastract 收集所有已发表的监管协会和 TF 结合位点，用于Komagataella phaffii（原毕赤酵母）、产油酵母解脂耶氏酵母、乳糖发酵物种Kluyveromyces lactis和Kluyveromyces marxianus，以及非常弱的耐酸食品腐败酵母Zygosaccharomyces bailii. 本评论文件的目的是宣传自 2019 年 NCYeastract 发布以来现有信息的更新，并提高社区对其潜力的认识，以帮助这些物种的日常工作，探索所有信息可在全球 YEASTRACT + 门户中获得。使用简单且广泛使用的示例，为多种工具提供了指导性开发：（i）直系同源基因的推断；(ii) 搜索推定的 TF 结合位点和 (iii) 转录调控网络的物种间比较和 TF 调控网络的预测，基于 YEASTRACT + 中可用于充分研究的物种的记录调控关联。还讨论了酵母社区对新 CommunityYeastract 平台的使用潜力。