This review provides a brief survey of chiral separation of pharmaceutically active substances published over the last 3 years (2018–2020). Chiral separation of drugs is an important area of research. The control of enantiomeric purity and determination of individual enantiomeric drug molecules is a necessity especially for clinical, analytical, and regulatory purposes. Among chromatographic resolution methods, high-performance liquid chromatography based on chiral stationary phases remains the most popular and effective method used for chiral separation of various drugs. In this review, attention is paid to several classes of chiral stationary phases that have been the most frequently used for drug enantioseparation during this period.

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HPLC 药物活性物质手性分离概述（2018-2020）

本综述对过去 3 年（2018-2020 年）发表的药物活性物质的手性分离进行了简要调查。药物的手性分离是一个重要的研究领域。对映体纯度的控制和单个对映体药物分子的测定是必要的，特别是对于临床、分析和监管目的。在色谱分离方法中，基于手性固定相的高效液相色谱法仍然是用于各种药物手性分离的最流行和最有效的方法。在这篇综述中，重点关注了这一时期最常用于药物对映体分离的几类手性固定相。

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