Abstract: Advanced research has revealed the crucial role of tumor microenvironment (TME) in tumorigenesis. TME consists of a complicated network with a variety of cell types including endothelial cells, pericytes, immune cells, cancer-associated fibroblasts (CAFs), cancer stem cells (CSCs) as well as the extracellular matrix (ECM). The TME-constituting cells interact with the cancerous cells through plenty of signaling mechanisms and pathways in a dynamical way, participating in tumor initiation, progression, metastasis, and response to therapies. Hence, TME is becoming an attractive therapeutic target in cancer treatment, exhibiting potential research interest and clinical benefits. Presently, the novel nanotechnology applied in TME regulation has made huge progress. The nanoparticles (NPs) can be designed as demand to precisely target TME components and to inhibit tumor progression through TME modulation. Moreover, nanotechnology-mediated drug delivery possesses many advantages including prolonged circulation time, enhanced bioavailability and decreased toxicity over traditional therapeutic modality. In this review, update information on TME remodeling through NPs-based targeted drug delivery strategies for anticancer therapy is summarized.

Keywords: tumor microenvironment, nanotherapeutics, cancer treatment, targeted delivery, regulation strategy


中文翻译：

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纳米粒子介导的靶向药物递送重塑肿瘤微环境以进行癌症治疗

摘要：高级研究揭示了肿瘤微环境 (TME) 在肿瘤发生中的关键作用。TME 由具有多种细胞类型的复杂网络组成，包括内皮细胞、周细胞、免疫细胞、癌症相关成纤维细胞 (CAF)、癌症干细胞 (CSC) 以及细胞外基质 (ECM)。TME 构成细胞通过大量信号机制和通路以动态方式与癌细胞相互作用，参与肿瘤的发生、进展、转移和对治疗的反应。因此，TME 正在成为癌症治疗中一个有吸引力的治疗靶点，表现出潜在的研究兴趣和临床益处。目前，应用于 TME 监管的新型纳米技术取得了巨大进展。纳米颗粒 (NPs) 可以根据需要进行设计，以精确靶向 TME 成分并通过 TME 调节抑制肿瘤进展。此外，与传统治疗方式相比，纳米技术介导的药物递送具有许多优点，包括延长循环时间、提高生物利用度和降低毒性。在这篇综述中，总结了通过基于 NPs 的靶向药物递送策略进行抗癌治疗的 TME 重塑的最新信息。

关键词：肿瘤微环境，纳米药物，癌症治疗，靶向给药，调控策略