In the current study, five isatin hydrazone schiff base linked acetylinic scaffolds have been synthesized via condensation reaction of isatin hydrazone with aldehydic groups. In order to identify the structure characteristics of the prepared hydrazone derivatives, IR, ¹H and ¹³C NMR spectroscopy, elemental analysis and X- ray crystallography were carried out. The antibacterial and antifungal activity of the derivatives against six bacterial strains (S. aureus, S. Pyogenes, E.coli, V. cholera, L. monocytogens and H.influenza) and seven fungal strains (C. glabrata,C. parapsilosis, C. krusei, C. albicans, C. tropicalis, C. keyfer, and C. neoformans) have been evaluated. All the compounds showed potent antibacterial activity with IC₅₀ ≈ 7.81 µM against H. influenza while the activity against fungal strains was less. Compounds a and c also had IC₅₀ ≈ 7.81 µM against S. Pyogens. Furthermore, the results of total antioxidant activity of hydrazone derivatives, expressed in terms of the ascorbic acid (mM) equivalents per mg of sample, indicates their superior bioactivity. These studies suggested that the istain hydrazone functionalized acetylenic derivatives could be an ideal biomaterial for antibacterial, antifungal and antioxidant applications. Besides this, these derivatives were transformed into isatin hydrazone appended 1,2,3 triazole based organotriethoxysilanes and their reaction conditions were optimised

在目前的研究中，通过靛红腙与醛基的缩合反应合成了五种靛红腙席夫碱连接的乙酰基支架。为了鉴定制备的腙衍生物的结构特征，进行了IR、¹ H和¹³ C NMR光谱、元素分析和X射线晶体学。衍生物对六种细菌菌株（金黄色葡萄球菌、化脓性链球菌、大肠杆菌、霍乱弧菌、单核细胞增生李斯特菌和流感嗜血杆菌）和七种真菌菌株（光滑念珠菌、近平滑念珠菌、近平滑念珠菌、 C. krusei、C. albicans、C.tropicalis、C. keyfer 和 C. neoformans) 进行了评估。所有化合物均显示出有效的抗菌活性，IC ₅₀ ≈ 7.81 µM 对流感嗜血杆菌，而对真菌菌株的活性较低。化合物 a 和 c对化脓性链球菌的IC ₅₀ ≈ 7.81 µM 。此外，腙衍生物的总抗氧化活性的结果，以每毫克样品的抗坏血酸 (mM) 当量表示，表明它们具有优越的生物活性。这些研究表明，腙腙功能化的炔属衍生物可能是抗菌、抗真菌和抗氧化应用的理想生物材料。除此之外，这些衍生物被转化为附加有 1,2,3 三唑基有机三乙氧基硅烷的靛红腙，并优化了它们的反应条件