ABSTRACT

Cancer is one of the serious diseases that endanger human health and bring a heavy burden to world economic development. Although the current targeted therapy and immunotherapy have achieved initial results, the emergence of drug resistance shows that the existing research is far from enough. In recent years, the tumor microenvironment has been found to be an important condition for tumor development and has profound research value. The SLC16 family is a group of monocarboxylic acid transporters involved in cancer metabolism and the formation of the tumor microenvironment. However, there have been no generalized cancer studies in the SLC16 family. In this study, we conducted a pan-cancer analysis of the SLC16 family. The results showed that multiple members of the SLC16 family could be used as prognostic indicators for many tumors, and were associated with immune invasion and tumor stem cells. Therefore, the SLC16 family has extensive exploration value in the future.

摘要

癌症是危害人类健康、给世界经济发展带来沉重负担的严重疾病之一。虽然目前的靶向治疗和免疫治疗已经取得初步成果，但耐药性的出现表明现有的研究还远远不够。近年来，人们发现肿瘤微环境是肿瘤发展的重要条件，具有深刻的研究价值。SLC16家族是一组参与癌症代谢和肿瘤微环境形成的单羧酸转运蛋白。然而，在 SLC16 家族中还没有普遍的癌症研究。在这项研究中，我们对 SLC16 家族进行了泛癌分析。结果表明，SLC16家族的多个成员可作为许多肿瘤的预后指标，并且与免疫侵袭和肿瘤干细胞有关。因此，SLC16家族在未来具有广泛的探索价值。