Purpose

Differences in multimodal imaging features between Asian and Caucasian eyes may contribute to our understanding of the etiology of the polypoidal choroidal vasculopathy (PCV). The purpose of this study was to compare the multimodal imaging features of Asian and Caucasian eyes with PCV.

Design

Cross-sectional, retrospective, multicenter, observational case series.

Methods

Consecutive treatment-naïve patients diagnosed with PCV based on indocyanine green angiography in accordance with published guidelines. Demographic and multimodal imaging findings based on color fundus photography, spectral domain optical coherence tomography, fluorescein angiography, and indocyanine green angiography were graded.

Results

A total of 250 participants with PCV (128 Asian vs 122 Caucasian participants) were included. Asian participants presented with lower best-corrected visual acuity (mean ± SD: 0.7 ± 0.6 logMAR vs 0.4 ± 0.3 logMAR; P < .001) compared with Caucasian participants. More Asian eyes had subretinal hemorrhage (mean ± SD: 53.9% vs 24.6%; P < .001) and larger areas of hemorrhage (mean ± SD: 7.5 ± 15.2 mm² vs 1.3 ± 3.3 mm²; P < .001). More Asian eyes had pachyvessels (84.4% vs 28.7%; P < .001), choroidal vascular hyperpermeability (70.3% vs 17.2%; P < .001), and widespread polypoidal lesions (19.5% vs 8.2%; P = .005), and Caucasian eyes had more drusen (79.5% vs 49.2%; P = .02).

Conclusions

Multimodal imaging analysis revealed ethnic differences in disease characteristics of PCV, suggesting pathophysiologic mechanism of the disease vary based on ethnicity.

中文翻译：

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亚洲和高加索人群息肉状脉络膜血管病变的多模态成像比较

目的

亚洲人和高加索人眼睛之间多模态成像特征的差异可能有助于我们了解息肉状脉络膜血管病（PCV）的病因。本研究的目的是比较亚洲和高加索人眼睛与 PCV 的多模态成像特征。

设计

横断面、回顾性、多中心、观察性病例系列。

方法

根据已发表的指南，基于吲哚菁绿血管造影诊断为 PCV 的连续未治疗患者。对基于彩色眼底摄影、光谱域光学相干断层扫描、荧光素血管造影和吲哚菁绿血管造影的人口统计学和多模态成像结果进行分级。

结果

共纳入 250 名 PCV 参与者（128 名亚洲人对 122 名高加索人参与者）。与白种人参与者相比，亚洲参与者的最佳矫正视力较低（平均值 ± SD：0.7 ± 0.6 logMAR vs 0.4 ± 0.3 logMAR；P < .001）。更多亚洲人的眼睛出现视网膜下出血（平均值 ± SD：53.9% 对 24.6%；P < .001）和更大的出血区域（平均值 ± SD：7.5 ± 15.2 mm ²对 1.3 ± 3.3 mm ²；P < .001）。更多亚洲人的眼睛有粗血管（84.4% 对 28.7%；P < .001）、脉络膜血管通透性过高（70.3% 对 17.2%；P < .001）和广泛的息肉状病变（19.5% 对 8.2%；P = .005），而高加索人的眼睛玻璃疣较多（79.5% vs 49.2%；P  = .02）。

结论

多模态成像分析揭示了 PCV 疾病特征的种族差异，表明该疾病的病理生理机制因种族而异。