Bothriechis schlegelii is a venomous snake found in Central and South America, mainly sighted in regions devoted to agriculture. However, in Colombia, little is known about its contribution to the total envenoming cases. Furthermore, there are no reports of the biochemical and functional activities of venoms from the southwest populations, and the differences respecting other populations are unknown. This study analyzed the protein profiles of venom samples obtained from three specimens originating from this region of Colombia using electrophoresis and chromatography. The lethality, edema-induction, hemorrhagic, defibrinating, coagulant, and indirect hemolytic activities were also evaluated. As a result, venoms were composed of proteins with a wide range of molecular weights, most of them below <37 kDa, with differences between male and female electrophoretic and chromatographic profiles. These variations were also observed in the evaluation of venom functional activities such as pro-coagulant, indirect hemolytic, and edema-inducing activities, whereas neither hemorrhagic nor defibrinating activities were detected. These results are also different considering reports with venom samples from other geographical locations, restating the existence of high intraspecific variability in B. schlegelii venoms, which could have relevant pathophysiological and therapeutic implications.

螟是一种发现于中美洲和南美洲的毒蛇，主要出现在农业区。然而，在哥伦比亚，人们对其对中毒病例总数的贡献知之甚少。此外，没有关于西南种群毒液的生化和功能活性的报道，其他种群的差异未知。本研究使用电泳和色谱法分析了来自哥伦比亚该地区的三个样本的毒液样本的蛋白质谱。还评估了致死性、水肿诱导、出血、去纤维蛋白、凝血和间接溶血活性。因此，毒液由分子量范围很广的蛋白质组成，其中大多数低于 37 kDa，男性和女性的电泳和色谱图之间存在差异。在评估毒液功能活动时也观察到这些变化，例如促凝、间接溶血和水肿诱导活动，而既没有检测到出血活动，也没有检测到去纤维蛋白活动。考虑到来自其他地理位置的毒液样本的报告，这些结果也有所不同，重申存在高种内变异性B. schlegelii毒液，可能具有相关的病理生理学和治疗意义。