Despite significant progress in the understanding of the frontotemporal dementias (FTDs), there remains no disease-modifying treatment for these conditions, and limited effective symptomatic treatment. Behavioural variant frontotemporal dementia (bvFTD) is the most common FTD syndrome, and is characterized by severe impairments in behaviour, personality and cognition. Neuropsychiatric symptoms are common features of bvFTD but are present in the other FTD syndromes. Current treatment strategies therefore focus on ameliorating the neuropsychiatric features. Here we review the rationale for current treatments related to each of the main neuropsychiatric symptoms forming the diagnostic criteria for bvFTD relevant to all FTD subtypes, and two additional symptoms not currently part of the diagnostic criteria: lack of insight and psychosis. Given the paucity of effective treatments for these symptoms, we highlight how contributing mechanisms delineated in cognitive neuroscience may inform future approaches to clinical trials and more precise symptomatic treatments for FTDs.

尽管在对额颞叶痴呆 (FTD) 的理解方面取得了重大进展，但仍然没有针对这些疾病的疾病缓解治疗，并且有效的对症治疗也有限。行为变异性额颞叶痴呆 (bvFTD) 是最常见的 FTD 综合征，其特征是行为、人格和认知的严重损害。神经精神症状是 bvFTD 的常见特征，但也存在于其他 FTD 综合征中。因此，当前的治疗策略侧重于改善神经精神特征。在这里，我们回顾了与构成与所有 FTD 亚型相关的 bvFTD 诊断标准的每个主要神经精神症状相关的当前治疗的基本原理，以及目前不属于诊断标准的两个附加症状：缺乏洞察力和精神病。