Abstract

The present study investigated Dioscorea deltoidea leaf extract (DDLE) for treatment of cisplatin-induced ovarian injury in rat model. DDLE treatment of the cisplatin-induced ovarian injury rats suppressed Follicle-stimulating hormone (FSH) release and promoted the estrogen E2 level in serum samples. Development of follicles was increased while as damage to ovarian cortex on day 14, 28, and 42 was inhibited in cisplatin-induced ovarian injury rats on treatment with DDLE. In cisplatin-induced ovarian injury rat model oxidative stress showed a significant increase because of reduction in the level of antioxidant enzyme activity. However, DDLE treatment led to a prominent increase in activity of antioxidant enzyme compared to the control group. Moreover, DDLE treatment regulated the expression of Nuclear factor erythroid 2-related factor 2 protein in cisplatin-induced ovarian injury rats. In conclusion, DDLE treatment prevents cisplatin-induced ovarian injury through inhibition of malondialdehyde (MDA) level and upregulation of superoxide dismutase (SOD) and catalase (CAT) activity.

中文翻译：

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三角叶薯蓣叶提取物 (DDLE) 通过调节氧化应激减轻顺铂引起的卵巢损伤

 抽象的

本研究探讨了薯蓣叶提取物（DDLE）对顺铂诱导的大鼠卵巢损伤的治疗作用。 DDLE 治疗顺铂诱导的卵巢损伤大鼠可抑制卵泡刺激素 (FSH) 的释放，并提高血清样本中雌激素 E2 的水平。在接受 DDLE 治疗的顺铂诱导的卵巢损伤大鼠中，卵泡发育增加，同时第 14、28 和 42 天的卵巢皮质损伤受到抑制。在顺铂诱导的卵巢损伤大鼠模型中，由于抗氧化酶活性水平降低，氧化应激显着增加。然而，与对照组相比，DDLE 治疗导致抗氧化酶活性显着增加。此外，DDLE治疗调节顺铂诱导的卵巢损伤大鼠中核因子红细胞2相关因子2蛋白的表达。总之，DDLE 治疗通过抑制丙二醛 (MDA) 水平和上调超氧化物歧化酶 (SOD) 和过氧化氢酶 (CAT) 活性来预防顺铂引起的卵巢损伤。