Abstract

The effect of proton pencil beam scanning in the dose range of 4.5–15 Gy on the radiosensitivity of mice under irradiation in two regions of the Bragg curve was studied according to the criteria of 30-day survival, dynamics of death, and average lifespan of mice. The relative biological effectiveness (RBE) value of protons relative to X-ray radiation before and at the Bragg peak determined by the LD_50/30 index was 0.86 and 0.94, respectively, and by the criterion of 30-day survival at a dose of 6.5 Gy it was 0.83 and 0.84, respectively. With similar RBE values for protons in different regions of the Bragg curve, significant differences in the dynamics of the course of radiation sickness were revealed, which indicates different damage to critical systems and organs of animals and the induction of compensatory mechanisms involved in the formation of stress responses at the organismal level.

中文翻译：

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小鼠体内质子笔形束扫描的相对生物效率评估

 抽象的

以30天生存、死亡动态和平均寿命为标准，研究4.5~15 Gy剂量范围的质子笔束扫描对布拉格曲线两个区域照射小鼠放射敏感性的影响。老鼠。通过 LD _50/30指数确定的布拉格峰之前和布拉格峰时质子相对于 X 射线辐射的相对生物有效性 (RBE) 值分别为 0.86 和 0.94，并以剂量​​为 30 天的存活率为标准6.5 Gy 分别为 0.83 和 0.84。布拉格曲线不同区域的质子 RBE 值相似，揭示了放射病病程动力学的显着差异，这表明对动物关键系统和器官的不同损害以及参与形成的补偿机制的诱导。机体水平的应激反应。