Preterm birth and subsequent timing of pubertal growth, menarche, and voice break,Pediatric Research

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Preterm birth and subsequent timing of pubertal growth, menarche, and voice break
Pediatric Research ( IF 3.1 ) Pub Date : 2021-08-24 , DOI: 10.1038/s41390-021-01690-5
Julia Suikkanen _{1,

2} , Markku Nurhonen ₁ , Tim J Cole ₃ , Marika Paalanne _{1,

4} , Hanna-Maria Matinolli _{1,

5,

6} , Marjaana Tikanmäki _{1,

4} , Marja Vääräsmäki _{4,

7} , Marjo-Riitta Järvelin _{8,

9,

10,

11} , Petteri Hovi _{1,

2} , Eero Kajantie _{1,

2,

4,

12}

Affiliation

Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland.
Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
UCL Great Ormond Street Institute of Child Health, London, UK.
PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Department of Child Psychiatry, University of Turku, Turku, Finland.
INVEST Research Flagship, University of Turku, Turku, Finland.
Children, Adolescents and Families Unit, Department of Welfare, Finnish Institute for Health and Welfare, Oulu, Finland.
Department of Epidemiology and Biostatistics, MRC-PHE Center for Environment & Health, School of Public Health, Imperial College London, London, UK.
Center for Life Course Epidemiology, Faculty of Medicine, University of Oulu, Oulu, Finland.
Biocenter Oulu, Oulu, Finland.
Unit of Primary Care, Oulu University Hospital, Oulu, Finland.
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

Background

We evaluated pubertal growth and pubertal timing of participants born preterm compared to those born at term.

Methods

In the ESTER Preterm Birth Study, we collected growth data and measured final height of men/women born very or moderately preterm (<34 gestational weeks, n = 52/55), late preterm (34–<37 weeks, 94/106), and term (≥37 weeks, 131/151), resulting in median 9 measurements at ≥6 years. Timing of menarche or voice break was self-reported. Peak height velocity (PHV, cm/year) and age at PHV (years) were compared with SuperImposition by Translation And Rotation (SITAR) model (sexes separately).

Results

Age at PHV (years) and PHV (cm/year) were similar in all gestational age groups. Compared to term controls, insignificant differences in age at PHV were 0.1 (95% CI: −0.2 to 0.4) years/0.2 (−0.1 to 0.4) for very or moderately/late preterm born men and −0.0 (−0.3 to 0.3)/−0.0 (−0.3 to 0.2) for women, respectively. Being born small for gestational age was not associated with pubertal growth. Age at menarche or voice break was similar in all the gestational age groups.

Conclusions

Timing of pubertal growth and age at menarche or voice break were similar in participants born preterm and at term.

Impact

Pubertal growth and pubertal timing were similar in preterm and term participants in a relatively large cohort with a wide range of gestational ages.
Previous literature indicates that small for gestational age is a risk for early puberty in term born children. This was not shown in preterm children.
While our study had limited power for children born very preterm, all children born preterm were not at increased risk for early puberty.

中文翻译：

早产和随后的青春期发育、月经初潮和声音中断时间

背景

我们评估了与足月出生的参与者相比，早产参与者的青春期生长和青春期时间。

方法

在 ESTER 早产研究中，我们收集了生长数据并测量了极早产或中度早产（<34 孕周，n = 52/55）、晚期早产（34–<37 周，94/106）的男性/女性的最终身高和足月（≥37 周，131/151），导致 ≥6 岁时的中位数 9 次测量。月经初潮或声音中断的时间是自我报告的。将峰值身高速度（PHV，厘米/年）和 PHV 时的年龄（岁）与平移和旋转 SuperImposition by Translation And Rotation (SITAR) 模型（男女分开）进行了比较。

结果

PHV 时的年龄（岁）和 PHV（厘米/年）在所有胎龄组中相似。与足月对照相比，极早产或中度/晚期早产男性的 PHV 年龄无显着差异为 0.1（95% CI：-0.2 至 0.4）岁/0.2（-0.1 至 0.4）和 -0.0（-0.3 至 0.3） /-0.0（-0.3 至 0.2）分别适用于女性。出生时小于胎龄儿与青春期发育无关。在所有胎龄组中，月经初潮或失声的年龄相似。