This single-centered, randomized, double-blind, placebo-controlled study reports the results of L-Citrulline treatment for 24 weeks in patients with post-polio syndrome (PPS). Twenty-nine patients were randomized and assigned into receiving a treatment of 15 g L-Citrulline or placebo. The primary endpoint was the change of the 6 min walking distance test. Secondary endpoints included motor function measure, quantitative muscle strength, quantitative MRI and self-reported impairment questionnaires. Patients receiving L-Citrulline walked 17.5 longer in the 6 min walking distance test when compared to placebo group, however not statistically significant (95% CI = -14.69; 49.68, p = 0.298). None of the secondary endpoints showed a statistically significant change in the L-Citrulline group when compared to placebo group. The motor function measure showed a change of -0.78 (95% CI= [-3.39; 1.83] p = 0.563). Muscle degeneration of leg muscles assessed with quantitative MRI indicated no significant change (estimate= -0.01, 95% CI =-0.13; 0.11, p = 0.869). L-Citrulline was safe and well tolerated. In conclusion, administration of 15 g L-Citrulline daily for 24 weeks to patients with PPS showed no beneficial treatment effect in timed muscle function.

这项单中心、随机、双盲、安慰剂对照研究报告了L-瓜氨酸治疗脊髓灰质炎后综合征 (PPS) 患者 24 周的结果。29 名患者被随机分配接受 15 g L-瓜氨酸或安慰剂治疗。主要终点是6分钟步行距离测试的变化。次要终点包括运动功能测量、定量肌肉力量、定量 MRI 和自我报告的损伤问卷。与安慰剂组相比，接受L-瓜氨酸的患者在 6 分钟步行距离测试中的步行时间长了 17.5，但没有统计学意义（95% CI = -14.69；49.68，p = 0.298）。与安慰剂组相比，L-瓜氨酸组的次要终点均未显示出统计学上的显着变化。运动功能测量显示变化为 -0.78 (95% CI= [-3.39; 1.83] p  = 0.563)。用定量 MRI 评估的腿部肌肉的肌肉退化表明没有显着变化（估计 = -0.01，95% CI =-0.13；0.11，p  = 0.869）。L-瓜氨酸安全且耐受性良好。总之，PPS 患者每天服用 15 g L-瓜氨酸，持续 24 周，在定时肌肉功能方面没有显示出有益的治疗效果。