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Genetically Predicted Coffee Consumption and Risk of Alzheimer’s Disease and Stroke
Journal of Alzheimer’s Disease ( IF 4 ) Pub Date : 2021-08-24 , DOI: 10.3233/jad-210678
Zhizhong Zhang 1 , Mengmeng Wang 2 , Shuai Yuan 3 , Huan Cai 4 , Shuang-Gen Zhu 5, 6 , Xinfeng Liu 1
Affiliation  

Background:Observational studies have reported that coffee consumption was associated with Alzheimer’s disease (AD) and stroke risk. However, the results are inconclusive. Objective:We aimed to evaluate whether genetically predicted coffee consumption is associated with AD and stroke using Mendelian randomization (MR) design. Methods:Summary-level data for AD (n = 54,162), ischemic stroke (n = 440,328), and intracerebral hemorrhage (ICH, n = 3,026) was adopted from publicly available databases. Summary-level data for coffee consumption were obtained from two genome-wide association studies, comprising up to 375,833 subjects. Results:Genetically predicted coffee consumption (cups/day) was associated with an increased risk of AD (OR = 1.26, 95%CI = 1.05–1.51). Moreover, genetically predicted 50%increase of coffee consumption was associated with an increased risk of ICH (OR: 2.27, 95%CI: 1.08–4.78) but a decreased risk of small vessel stroke (OR: 0.71, 95%CI: 0.51–0.996). Estimate for AD and ICH in FinnGen consortium is directionally consistent. Combined analysis of different databases further confirmed that genetically predicted coffee consumption was associated with an increased risk of AD and ICH. In the multivariable MR analysis, genetically predicted coffee consumption retained a stable effect with AD and ICH when adjusting for smoking (p < 0.05), while the association with AD attenuated when adjusting for alcohol use. Conclusion:Our results indicate that genetically predicted coffee consumption may be associated with an increased risk of AD and ICH. The underlying biological mechanisms warrant further study.

中文翻译:

基因预测的咖啡消费量和阿尔茨海默病和中风的风险

背景:观察性研究报告称,咖啡消费与阿尔茨海默病 (AD) 和中风风险有关。然而,结果尚无定论。目的:我们旨在使用孟德尔随机化 (MR) 设计评估基因预测的咖啡消费是否与 AD 和中风相关。方法:从公开可用的数据库中采用 AD(n = 54,162)、缺血性卒中(n = 440,328)和脑出血(ICH,n = 3,026)的概要数据。咖啡消费的概要数据来自两项全基因组关联研究,包括多达 375,833 名受试者。结果:遗传预测的咖啡消费量(杯/天)与 AD 风险增加相关(OR = 1.26,95%CI = 1.05–1.51)。而且,遗传预测咖啡摄入量增加 50% 与 ICH 风险增加相关(OR:2.27,95%CI:1.08-4.78),但小血管卒中风险降低(OR:0.71,95%CI:0.51-0.996) . FinnGen 联盟中对 AD 和 ICH 的估计在方向上是一致的。对不同数据库的综合分析进一步证实,基因预测的咖啡消费与 AD 和 ICH 风险增加有关。在多变量 MR 分析中,基因预测的咖啡消费量在调整吸烟后对 AD 和 ICH 保持稳定的影响(p < 0.05),而在调整酒精使用时与 AD 的相关性减弱。结论:我们的结果表明,基因预测的咖啡消费可能与 AD 和 ICH 风险增加有关。
更新日期:2021-08-24
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