Background and Purpose: For prevention of cerebrovascular diseases at younger age, it is important to understand the risk factors occurring early in life. We investigated the relationship between mothers’ general health during pregnancy and the offspring’s risk of cerebrovascular disease in age of 15 to 52 years.

Methods: Within the population-based prospective Northern Finland Birth Cohort 1966, 11,926 persons were followed from antenatal period to 52 years of age. Information on their mother’s ill health conditions, i.e., hospitalizations, chronic diseases, medications, vitamin or iron supplement, fever, anemia, mood, and smoking was collected from 24th gestational week onwards. Ischemic and hemorrhagic cerebrovascular diseases of the offspring were identified from national registers in Finland. Cox proportional hazard models were used to estimate the association of mother’s health conditions with incidence of cerebrovascular disease in the offspring, with adjustments for potential confounders.

Results: During 565,585 person-years of follow-up, 449 (2.8%) of the offspring had a cerebrovascular disease. Hospitalization during pregnancy was associated with an increased risk of cerebrovascular disease in the offspring (hazard ratio (HR)=1.49; 95% confidence interval (CI) 1.06-2.08) after adjustment for confounders, as was having more than three ill health conditions (HR=1.89; CI 1.14-3.11). Not using vitamin or iron supplement associated with increased risk for cerebrovascular disease in the offspring (HR=1.39; CI 1.01-1.89).

Conclusions: The results suggest that the risk of cerebrovascular disease may start as early as during the antenatal period, and the health characteristics of mothers during pregnancy may play a role in cerebrovascular disease risk of the offspring.

背景与目的：为了预防脑血管疾病的年轻化，了解生命早期发生的危险因素非常重要。我们调查了母亲在怀孕期间的总体健康与 15 至 52 岁的后代患脑血管疾病的风险之间的关系。

方法：在 1966 年基于人群的前瞻性芬兰北部出生队列中，对 11,926 人进行了从产前期到 52 岁的随访。从第 24 孕周开始收集关于他们母亲健康状况不佳的信息，即住院、慢性病、药物、维生素或铁补充剂、发烧、贫血、情绪和吸烟。从芬兰的国家登记册中确定了后代的缺血性和出血性脑血管疾病。Cox 比例风险模型用于估计母亲的健康状况与后代脑血管疾病发病率之间的关系，并对潜在的混杂因素进行了调整。

结果：在 565,585 人年的随访中，449 名 (2.8%) 的后代患有脑血管疾病。调整混杂因素后，怀孕期间住院与后代脑血管疾病风险增加相关（风险比 (HR)=1.49；95% 置信区间 (CI) 1.06-2.08），以及具有超过三种健康状况的情况。 HR=1.89；CI 1.14-3.11)。不使用与后代脑血管疾病风险增加相关的维生素或铁补充剂（HR=1.39；CI 1.01-1.89）。

结论：结果提示脑血管病风险可能早在产前就开始出现，母亲孕期健康特征可能对后代脑血管病风险有一定影响。