Objective: Many epidemiological studies have observed the association of air pollutant exposure with the onset, progression, and mortality of stroke. The aim of this study was to investigate the associations of air pollutants, including SO2, NO2, O3, CO, and PM10, with stroke according to exposure duration.

Methods: Data from the Korean National Health Insurance Service-Health Screening Cohort from 2002 to 2015 were obtained. The 21,240 patients who were admitted for or died due to stroke were 1:4 matched for age, sex, income, and region of residence with 84,960 control participants. The meteorological factors of mean, highest, and lowest temperatures; relative humidity; ambient atmospheric pressure; and air pollutant concentrations (SO2, NO2, O3, CO, and PM10) were analyzed to determine their associations with stroke. The odds ratios (ORs) for stroke after exposure to each meteorological factor and air pollutant at 7 and 30 days were calculated in the stroke and control groups. Subgroup analyses were conducted according to age, sex, income, and region of residence.

Results: The OR associated with 7 days of exposure to CO was 1.16 (95% CI=1.04-1.31) in stroke patients. For 30 days of exposure, the OR associated with CO was 1.16 (95% CI=1.02-1.32) in stroke patients. Seven and 30 days of NO2 exposure were inversely associated with stroke. The OR associated with 7 days of exposure to O3 was 1.16 (95% CI=1.01–1.32) in ischemic stroke patients. Both ischemic and hemorrhagic stroke had negative associations with 7 and 30 days of NO2 exposure.

Conclusion: Both short- and long-term exposure to CO were related to stroke.

目的：许多流行病学研究已经观察到空气污染物暴露与中风的发病、进展和死亡率之间的关系。本研究的目的是根据暴露时间调查空气污染物（包括 SO2、NO2、O3、CO 和 PM10）与中风的关系。

方法：获得韩国国民健康保险服务-健康筛查队列 2002 年至 2015 年的数据。因中风入院或死亡的 21,240 名患者的年龄、性别、收入和居住地区与 84,960 名对照参与者按 1:4 匹配。平均气温、最高气温和最低气温的气象因素；相对湿度; 环境大气压；分析空气污染物浓度（SO2、NO2、O3、CO 和 PM10）以确定它们与中风的关系。计算中风组和对照组在 7 天和 30 天暴露于每种气象因素和空气污染物后中风的优势比 (OR)。根据年龄、性别、收入和居住地区进行亚组分析。

结果：在中风患者中，与 CO 暴露 7 天相关的 OR 为 1.16 (95% CI = 1.04-1.31)。对于 30 天的暴露，中风患者与 CO 相关的 OR 为 1.16 (95% CI = 1.02-1.32)。7 天和 30 天的 NO2 暴露与中风呈负相关。在缺血性卒中患者中，与 7 天 O3 暴露相关的 OR 为 1.16 (95% CI=1.01–1.32)。缺血性和出血性中风都与 7 天和 30 天的 NO2 暴露呈负相关。

结论：短期和长期接触一氧化碳都与卒中有关。