Increased Menopausal Age Reduces the Risk of Parkinson's Disease: A Mendelian Randomization Approach,Movement Disorders

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Increased Menopausal Age Reduces the Risk of Parkinson's Disease: A Mendelian Randomization Approach
Movement Disorders ( IF 8.6 ) Pub Date : 2021-08-23 , DOI: 10.1002/mds.28760
Cynthia D J Kusters ₁ , Kimberly C Paul ₂ , Aline Duarte Folle ₃ , Adrienne M Keener _{2,

4} , Jeff M Bronstein _{2,

5} , Lars Bertram _{6,

7} , Johnni Hansen ₈ , Steve Horvath _{1,

9} , Janet S Sinsheimer _{1,

9,

10} , Christina M Lill _{11,

12} , Beate R Ritz _{2,

3,

13}

Affiliation

Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA.
Parkinson's Disease Research, Education, and Clinical Center, Greater Los Angeles Veterans Affairs Medical Center, Los Angeles, California, USA.
Brain Research Institute, University of California, Los Angeles, California, USA.
Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany.
Department of Psychology, Centre for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway.
Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.
Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, California, USA.
Department of Computational Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Translational Epidemiology Group, Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany.
Ageing Epidemiology Research Unit, School of Public Health, Imperial College, London, United Kingdom.
Department of Environmental Health, Fielding School of Public Health, University of California, Los Angeles, California, USA.

Studies of Parkinson's disease (PD) and the association with age at menarche or menopause have reported inconsistent findings. Mendelian randomization (MR) may address measurement errors because of difficulties accurately reporting the age these life events occur.

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