Huntingtin Polyglutamine Fragments Are a Substrate for Hsp104 in Yeast,Molecular and Cellular Biology

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Huntingtin Polyglutamine Fragments Are a Substrate for Hsp104 in Yeast
Molecular and Cellular Biology ( IF 3.2 ) Pub Date : 2021-08-23 , DOI: 10.1128/mcb.00122-21
Nicole J Wayne ₁ , Katherine E Dembny ₁ , Tyler Pease ₁ , Farrin Saba ₁ , Xiaohong Zhao ₁ , Daniel C Masison ₂ , Lois E Greene ₁

Affiliation

The aggregation of huntingtin fragments with expanded polyglutamine repeat regions (HttpolyQ) that cause Huntington’s disease depends on the presence of a prion with an amyloid conformation in yeast. As a result of this relationship, HttpolyQ aggregation ...

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