Background: Myelofibrosis (MF) is often associated with chronic myeloid leukemia, myelodysplastic syndrome and primary myeloproliferative neoplasms (MPN), but few number cases of malignant lymphoma with myelofibrosis was reported, and a few cases about follicular lymphoma with MF were found. Here we described a case of follicular lymphoma (FL) complicated by myelofibrosis.
Case Presentation: A 43-year-old man was diagnosed with follicular lymphoma (FL) complicated by MF, besides, the lymphoma staging of this patient was AnnArbor IV B. The cytokines of plated-derived growth factor (PDGF), basic fibroblast growth factor (b-FGF), vascular endothelial growth factor (VEGF), tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), interleukin-2 (IL-2), and transforming growth factor-β (TGF-β) were positive, while JAK2V617F, MPL, and CALR mutations were negative. After first course of chemotherapy, the peripheral blood and MF improved. The systemic superficial lymph nodes and spleen were significantly narrowed after the third cycle of chemotherapy.
Conclusion: The production of various cytokines, such as b-FGF, TNF-α, TGF-β, PDGF, IL-1β, IL-2, IL-6, IL-10, may contribute to the development of MF.



中文翻译：

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滤泡性淋巴瘤并发骨髓纤维化：一例文献复习报告

背景：骨髓纤维化（MF）常与慢性粒细胞白血病、骨髓增生异常综合征和原发性骨髓增生性肿瘤（MPN）相关，但恶性淋巴瘤伴骨髓纤维化的报道较少，滤泡性淋巴瘤伴MF的病例较少。在这里，我们描述了一个合并骨髓纤维化的滤泡性淋巴瘤 (FL) 病例。
案例介绍：一名 43 岁男性被诊断为滤泡性淋巴瘤（FL）并发 MF，该患者的淋巴瘤分期为 AnnArbor IV B。 -FGF)、血管内皮生长因子 (VEGF)、肿瘤坏死因子 α (TNF-α)、白细胞介素-1β (IL-1β)、白细胞介素-2 (IL-2) 和转化生长因子-β (TGF-β) ) 为阳性，而 JAK2V617F、MPL 和 CALR 突变为阴性。化疗第一疗程后，外周血和MF有所改善。第三周期化疗后全身浅表淋巴结和脾脏明显变窄。
结论： b-FGF、TNF-α、TGF-β、PDGF、IL-1β、IL-2、IL-6、IL-10等多种细胞因子的产生可能促进MF的发生发展。