Abstract: Ferroptosis is a special form of regulatory cell death caused by the accumulation of intracellular iron and lipid peroxidation. Here, we summarize the research progress on ferroptosis in hepatocellular carcinoma (HCC), trace the development of the concept of ferroptosis and its key regulatory factors, and discuss the application value of ferroptosis in the treatment of HCC from different perspectives. We believe that exploring the relationship between ferroptosis and HCC and clarifying the metabolism and expression of ferroptosis-specific genes and molecules will accelerate the development of novel ferroptosis-related molecules as HCC markers and therapeutic targets. We hope to provide a theoretical basis for better diagnosis and treatment to effectively improve the prognosis of patients with HCC.

Keywords: hepatocellular carcinoma, ferroptosis, iron, regulatory cell death, lipid peroxidation, sorafenib


中文翻译：

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肝细胞癌中铁死亡的分子靶点

摘要：铁死亡是细胞内铁积累和脂质过氧化引起的一种特殊形式的调节性细胞死亡。在此，我们总结肝细胞癌（HCC）中铁死亡的研究进展，追溯铁死亡概念的发展及其关键调控因素，并从不同角度探讨铁死亡在HCC治疗中的应用价值。我们相信，探索铁死亡与 HCC 之间的关系，阐明铁死亡特异性基因和分子的代谢和表达，将加速新的铁死亡相关分子作为 HCC 标志物和治疗靶点的发展。我们希望为更好的诊断和治疗提供理论依据，以有效改善HCC患者的预后。

关键词：肝细胞癌，铁死亡，铁，调节性细胞死亡，脂质过氧化，索拉非尼