Efficient topical delivery of antifungal drugs, such as lanoconazole (LCZ), is challenging due to the limited water solubility and required prolonged duration of treatment. In this study, LCZ-loaded emulsions stabilized with cellulose nanocrystals grafted with polyphosphoesters (LCZ-loaded CP-PEs) were developed to enhance the anti-inflammatory efficacy of LCZ on skin. A high drug-loading efficiency (>80%) of LCZ in CP-PEs with a small mean droplet size of 1.0–1.5 μm was achieved. The sustained release of LCZ and superior skin permeation of the LCZ-loaded CP-PEs, likely due to the excellent stability and rigidity of oil droplets, assured prolonged local action. In addition, the excellent anti-inflammatory efficacy of the LCZ-loaded CP-PEs was clarified using a mouse ear model of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation. Treatment with the LCZ-loaded CP-PEs significantly reduced auricular thickness compared to treatments with a commercial ointment and control solution containing LCZ. These results suggest that LCZ-loaded CP-PEs are a promising alternative for the treatment of inflammatory skin diseases, such as tinea pedis.

由于有限的水溶性和需要延长的治疗时间，抗真菌药物，如拉诺康唑 (LCZ) 的有效局部给药具有挑战性。在这项研究中，开发了用接枝聚磷酸酯的纤维素纳米晶体稳定的负载 LCZ 的乳液（负载 LCZ 的 CP-PEs），以增强 LCZ 对皮肤的抗炎作用。CP-PE 中 LCZ 的载药效率高（>80%），平均液滴尺寸为 1.0-1.5 μm。LCZ 的持续释放和负载 LCZ 的 CP-PE 的卓越皮肤渗透性，可能是由于油滴的出色稳定性和刚性，确保了长时间的局部作用。此外，使用 12-O-十四烷酰佛波醇-13-乙酸酯 (TPA) 诱导的炎症的小鼠耳模型阐明了负载 LCZ 的 CP-PE 的优异抗炎功效。与使用含有 LCZ 的商业软膏和对照溶液处理相比，使用负载 LCZ 的 CP-PE 处理显着降低了耳廓厚度。这些结果表明，负载 LCZ 的 CP-PE 是治疗炎症性皮肤病（如足癣）的一种有前途的替代品。