This study aimed to compare outcomes between ankylosing spondylitis (AS) treated with and without bisphosphonate (BP; non-BP) through a meta-analysis. The Medline (via PubMed), Cochrane, Scopus, and Embase databases were searched for studies that evaluated the outcomes of AS, including patient age, disease duration, disease activity, and bone mineral density (BMD), published between January 2000 and March 2020. Two authors extracted the data independently. Any discrepancies were resolved by a consensus. Six comparative studies were identified. No significant differences were found between the BP and non-BP groups in terms of demographic characteristics, disease activity, and BMD, except for follow-up erythrocyte sedimentation rate (ESR). The follow-up ESR was higher in the BP than in the non-BP group. A literature review identified six comparative studies reporting the outcomes of BP and non-BP treatments for AS. Despite the heterogeneity, a limited number of meta-analyses reported that BP treatment was not clearly better than non-BP treatment. Hence, further large-scale multicenter studies are required to validate our results.

本研究旨在通过荟萃分析比较使用和不使用双膦酸盐（BP；非 BP）治疗的强直性脊柱炎 (AS) 的结果。在 Medline（通过 PubMed）、Cochrane、Scopus 和 Embase 数据库中搜索评估 AS 结果的研究，包括患者年龄、疾病持续时间、疾病活动度和骨矿物质密度 (BMD)，发表于 2000 年 1 月至 2020 年 3 月之间. 两位作者独立提取数据。任何分歧都通过协商一致解决。确定了六项比较研究。除了随访红细胞沉降率 (ESR) 外，BP 组和非 BP 组在人口统计学特征、疾病活动度和 BMD 方面没有显着差异。BP 组的随访 ESR 高于非 BP 组。一项文献综述确定了六项比较研究，报告了 BP 和非 BP 治疗 AS 的结果。尽管存在异质性，但有限数量的荟萃分析报告称，BP 治疗并不明显优于非 BP 治疗。因此，需要进一步的大规模多中心研究来验证我们的结果。