Abstract

In this study, a simple and efficient synthesis reaction was used to prepare Bis (dihydropyrimidinone) derivatives through Biginelli condensation reaction of terephthalic aldehyde, 1,3-dicarbonyl compounds and (thio) urea or guanidine and tetrahydro-4H-chromenes via one pot condensation of aromatic aldehydes, malononitrile, and dimedone with Ag₂O/GO/TiO₂ composite nanostructures as the catalyst. The structural functionalities and morphological observations of catalyst were obtained using characterization techniques of field emission scanning electron microscopy, X-ray diffraction, Fourier transfer infrared (FT-IR) spectroscopy and transmission electron microscope. The structures of Bis (dihydropyrimidinone) and tetrahydro-4H-chromenes were confirmed by FT-IR, NMR, and mass spectroscopy. Excellent yields of products, simple reaction process and simple work-up are attractive features of these effective synthesis methods.

摘要

本研究采用简单高效的合成反应，通过对苯二甲醛、1,3-二羰基化合物和（硫代）脲或胍与四氢-4H-色烯的Biginelli缩合反应，通过一锅法缩合制备双（二氢嘧啶酮）衍生物芳香醛、丙二腈和双甲酮与 Ag ₂ O/GO/TiO ₂复合纳米结构作为催化剂。利用场发射扫描电子显微镜、X 射线衍射、傅里叶转移红外 (FT-IR) 光谱和透射电子显微镜等表征技术，获得了催化剂的结构功能和形貌观察结果。Bis (dihydropyrimidinone) 和 tetrahydro-4H-chromene 的结构通过 FT-IR、NMR 和质谱得到证实。优异的产品收率、简单的反应过程和简单的后处理是这些有效合成方法的吸引人的特征。