Collagen mineralization and its applications in hard tissue repair,Materials Chemistry Frontiers

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Collagen mineralization and its applications in hard tissue repair
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2021-08-07 , DOI: 10.1039/d1qm00901j
Shanshan Wu ₁ , Yi Chen ₁ , Xiaodong Guo ₂ , Yuzhou Wu ₁

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Vertebrate hard tissues (teeth and bones) are formed through a mineralization process in living systems, and mineralized collagen is the basic building block of these biological materials. Mineralized collagen is an organic–inorganic composite material formed from collagen molecules and nano-calcium phosphate minerals. Understanding the principle, process, and regulation mechanism of collagen mineralization in organisms is of great significance for the design of materials for hard tissue regeneration. In this review, the assembly of collagen molecules, the hierarchical structural characteristics of mineralized collagen, the interactions between collagen molecules and non-collagen proteins with calcium phosphate materials, the nucleation theory relating to collagen mineralization, and the applications of collagen mineralization technology in hard tissue repair are discussed. This review aims to provide a reference for the in-depth study of the collagen biomineralization mechanism and applications relating to hard tissue regeneration and repair.

中文翻译：

胶原矿化及其在硬组织修复中的应用

脊椎动物的硬组织（牙齿和骨骼）是通过生命系统中的矿化过程形成的，矿化胶原蛋白是这些生物材料的基本组成部分。矿化胶原蛋白是由胶原蛋白分子和纳米磷酸钙矿物质形成的有机-无机复合材料。了解生物体内胶原矿化的原理、过程和调控机制，对于硬组织再生材料的设计具有重要意义。在这篇综述中，胶原分子的组装，矿化胶原的层次结构特征，胶原分子与非胶原蛋白与磷酸钙材料的相互作用，与胶原矿化相关的成核理论，并讨论了胶原矿化技术在硬组织修复中的应用。本综述旨在为深入研究胶原生物矿化机制及其在硬组织再生修复中的应用提供参考。

更新日期：2021-08-23

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