Poor wound healing is a common complication in diabetic patients. It often leads to intractable infections and lower limb amputations and is associated with cardiovascular morbidity and mortality. NcRNAs, which can regulate gene expression, have emerged as important regulators of various physiological processes. Herein, we summarize the diverse roles of ncRNAs in the key stages of diabetic wound healing, including inflammation, angiogenesis, re-epithelialization, and extracellular matrix remodeling. Meanwhile, the potential use of ncRNAs as novel therapeutic targets for wound healing in diabetic patients is also discussed. In addition, we summarize the role of RNA-binding proteins (RBPs) in the regulation of gene expression and signaling pathways during skin repair, which may provide opportunities for therapeutic intervention for this potentially devastating disease. However, so far, research on the modulated drug based on ncRNAs that lead to significantly altered gene expression in diabetic patients is scarce. We have compiled some drugs that may be able to modulate ncRNAs, which significantly regulate the gene expression in diabetic patients.

伤口愈合不良是糖尿病患者常见的并发症。它经常导致顽固性感染和下肢截肢，并与心血管疾病的发病率和死亡率有关。可以调节基因表达的 NcRNA 已成为各种生理过程的重要调节剂。在此，我们总结了 ncRNA 在糖尿病伤口愈合关键阶段的不同作用，包括炎症、血管生成、再上皮化和细胞外基质重塑。同时，还讨论了 ncRNA 作为糖尿病患者伤口愈合新治疗靶点的潜在用途。此外，我们总结了 RNA 结合蛋白 (RBP) 在皮肤修复过程中调节基因表达和信号通路中的作用，这可能为这种潜在的破坏性疾病提供治疗干预的机会。然而，到目前为止，关于导致糖尿病患者基因表达显着改变的基于 ncRNA 的调节药物的研究还很少。我们编制了一些可能能够调节 ncRNA 的药物，这些药物可显着调节糖尿病患者的基因表达。