Undermining new mediators involved in the development and progression of cardiovascular diseases (CVDs) is vital for better disease management. Existing studies implicate a crucial role for inflammation and inflammatory cells, particularly mast cells, in cardiac diseases. Interestingly, the mast cell mediator, histamine, and its receptors profoundly impact the pathophysiology of the heart, resulting in hypertension-induced cardiac hypertrophy and other cardiac anomalies. In this review, we provide a detailed description of mast cell activation, mediators, and histamine receptors, with a particular focus on histamine 2 receptors (H2Rs). Preclinical and clinical studies using histamine receptor antagonists report improvement in cardiac function. Insights into the precise function of histamine receptors will aid in developing novel therapies and pave the way for repurposing antihistamines for cardiovascular diseases.

破坏参与心血管疾病 (CVD) 发展和进展的新介质对于更好的疾病管理至关重要。现有研究暗示炎症和炎症细胞，特别是肥大细胞在心脏病中的关键作用。有趣的是，肥大细胞介质、组胺及其受体深刻影响心脏的病理生理，导致高血压引起的心脏肥大和其他心脏异常。在这篇综述中，我们详细描述了肥大细胞激活、介质和组胺受体，特别关注组胺 2 受体 (H2Rs)。使用组胺受体拮抗剂的临床前和临床研究报告了心脏功能的改善。