Instead of causing immediate sterility, loss of the C. elegans PIWI protein PRG-1 leads to accumulated infertility after tens of generations. In this issue of Developmental Cell, Wahba et al. show that this correlates with aberrant RNA interference pathway-dependent feed forward amplification of ribosomal siRNAs—the proposed accumulative sterility factor.

中文翻译：

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谁在看守望者？RNAi 通路衍生的核糖体小 RNA 在没有 piRNA 的情况下迅速发展

线虫PIWI 蛋白 PRG-1 的缺失不会导致立即不育，而是在数十代后导致累积不育。在本期Developmental Cell 中，Wahba 等人。表明这与核糖体 siRNA 的异常 RNA 干扰通路依赖性前馈扩增相关 - 建议的累积不育因子。