In the present study, a polymeric micelle based on amphiphilic block copolymer, namely poly(methacrylated methyl lithocholate)-block-poly(oligoethylene glycol methacrylate) (PMML-b-POEGMA) bearing bile acid moiety is prepared via sequential photo-initiated free radical polymerizations, and its drug carrying capacity is investigated using doxorubicin hydrochloride (DOX) as a model drug. For this purpose, two-step procedure is applied in the presence of phenylbis (2,4,6-trimethylbenzoyl)phosphine oxide (BAPO) as bifunctional photo initiator. Based on spectroscopic and chromatographic analyses, the desired amphiphilic block copolymer (PMML-b-POEGMA) is successfully synthesized by wavelength-selective free radical photopolymerization under mild conditions. Finally, the DOX drug is loaded into the PMML-b-POEGMA micelles and then drug release behavior is investigated at two different pH (5.5 and 7.4) values. It is concluded from the results that PMML-b-POEGMA micelles may be used as an efficient nanocarrier to deliver conventional anti-cancer drugs for combination chemotherapy.

中文翻译：

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胆汁酸基聚合物胶束作为阿霉素药物载体的合成与表征

在本研究中，聚合物胶束基于两亲性嵌段共聚物，即聚（甲基丙烯酸甲基lithocholate） -嵌段-聚（低聚乙二醇甲基丙烯酸酯）（PMML- b -POEGMA）轴承胆汁酸部分通过制备连续的光引发自由基聚合，并使用盐酸多柔比星（DOX）作为模型药物研究其载药能力。为此，在作为双功能光引发剂的苯基双 (2,4,6-三甲基苯甲酰基) 氧化膦 (BAPO) 存在下应用两步程序。基于光谱和色谱分析，所需的两亲嵌段共聚物 (PMML- b-POEGMA) 在温和条件下通过波长选择性自由基光聚合成功合成。最后，将 DOX 药物加载到 PMML- b- POEGMA 胶束中，然后在两个不同的 pH（5.5 和 7.4）值下研究药物释放行为。结果表明，PMML- b- POEGMA胶束可作为一种有效的纳米载体，为联合化疗递送常规抗癌药物。