As a key component of Wnt signaling, Dishevelled (Dvl/Dsh) plays essential roles in development processes and adult tissue homeostasis in multicellular organisms, and its deregulation results in human development disorders and other diseases. Dvl integrates and relays complex Wnt signals by acting as a branch-point of β-catenin-dependent canonical and β-catenin-independent noncanonical pathways. It dynamically interacts with multiple proteins to modulate Wnt signaling, while its activity and stability are tightly controlled by other proteins. This Review summarizes the current understanding of regulation of Dvl activity, localization, and stability by post-translational modifications, aggregation, and autophagy, and the impacts on Dvl function in both Wnt signaling and biological processes.

作为 Wnt 信号传导的关键组成部分，Disheveled (Dvl/Dsh) 在多细胞生物的发育过程和成体组织稳态中发挥着重要作用，其失调导致人类发育障碍和其他疾病。Dvl 通过充当依赖 β-连环蛋白的经典途径和不依赖β-连环蛋白的非经典途径的分支点来整合和传递复杂的 Wnt 信号。它与多种蛋白质动态相互作用以调节 Wnt 信号，而其活性和稳定性受到其他蛋白质的严格控制。本综述总结了目前对通过翻译后修饰、聚集和自噬调节 Dvl 活性、定位和稳定性的理解，以及 Wnt 信号传导和生物过程中对 Dvl 功能的影响。