Drug resistance may pre-exist or arise during therapy, but how precisely cancer treatment itself influences these processes is a major gap in the understanding of therapy resistance in cancer. A study of acute lymphocytic leukemia now provides direct evidence of thiopurine-induced mutations in the gene encoding the tumor suppressor p53 that result in multi-drug-resistant relapse.

中文翻译：

---

dMMR 和硫嘌呤链 TP53 用于 ALL 复发

耐药性可能在治疗过程中预先存在或出现，但癌症治疗本身如何精确地影响这些过程是理解癌症治疗耐药性的主要差距。一项对急性淋巴细胞白血病的研究现在提供了硫嘌呤诱导的编码肿瘤抑制基因 p53 的基因突变的直接证据，该突变导致多重耐药性复发。