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Clinical features and outcomes of 1845 patients with follicular lymphoma: a real-world multicenter experience in China
Journal of Hematology & Oncology ( IF 29.5 ) Pub Date : 2021-08-23 , DOI: 10.1186/s13045-021-01139-6
Jie Zha 1, 2 , Liyuan Fan 1, 2 , Shuhua Yi 3 , Haifeng Yu 4, 5 , Zhong Zheng 6 , Wei Xu 7 , Manman Deng 1, 2 , Zhijuan Lin 1, 2 , Zhifeng Li 1, 2 , Lingyan Ping 8 , Xiaohua He 9, 10, 11 , Feili Chen 12 , Ying Xie 13 , Biyun Chen 13 , Huilai Zhang 14 , Li Wang 7 , Kaiyang Ding 15 , Wenyu Li 12 , Haiyan Yang 4, 5 , Weili Zhao 6 , Lugui Qiu 3 , Zhiming Li 9, 10, 11 , Yuqin Song 8 , Bing Xu 1, 2
Affiliation  

Clinical features and outcomes of FL patients in Chinese population are limited, thus promoting us to perform this analysis on a large cohort of 1845 patients with FL enrolled from nine medical centers nationwide in China. In this cohort, the median age of patients at diagnosis was 53 years, which was comparable to that reported previously for Chinese FL patients (49–51 years) but younger than that for Western FL patients (60–65 years). In contrast with Western patients, Chinese FL patients more likely involved extranodal sites but less frequently infiltrated bone marrow. Other clinical characteristics were comparable between two populations. In this study, 91% of patients were managed with chemotherapy, yielding 72% and 46% of overall-response rate and complete remission. After median 55-month follow-up, 5-year progressive-free and overall survival were 61% and 89%, respectively. Both were analogous to those reported in prior Chinese and Western studies. Consistent with published data, addition of rituximab into both induction (Ri) and maintenance (Rm) treatment led to the most favorable outcomes. Interestingly, Ri only had better outcomes than Rm only. Notably, 7% of patients experienced histologic transformation (HT) and correlated with poor survival. Of the transformed FL cases, 3% and 4% of HT events occurred prior to or post-treatment, respectively. Importantly, the latter displayed worse outcomes than the former. Altogether, this study provides real-world information of the largest cohort of FL patients so far in China, which might lay a foundation for clinical investigation of Chinese FL in future.
更新日期:2021-08-23
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