Gammaherpesviruses are ubiquitous pathogens that establish lifelong infections in the vast majority of adults worldwide. Importantly, these viruses are associated with numerous malignancies and are responsible for significant human cancer burden. These virus-associated cancers are due, in part, to the ability of gammaherpesviruses to successfully evade the innate immune response throughout the course of infection. In this review we will summarize the current understanding of how gammaherpesviruses are detected by innate immune sensors, how these viruses evade recognition by host cells, and how this knowledge can inform novel therapeutic approaches for these viruses and their associated diseases.

Gammaherpesviruses 是普遍存在的病原体，在全世界绝大多数成年人中建立终生感染。重要的是，这些病毒与许多恶性肿瘤有关，是造成人类癌症负担的主要原因。这些与病毒相关的癌症部分是由于 γ 疱疹病毒在整个感染过程中成功逃避先天免疫反应的能力。在这篇综述中，我们将总结目前对先天免疫传感器如何检测 gammaherpesviruses、这些病毒如何逃避宿主细胞的识别以及这些知识如何为这些病毒及其相关疾病的新治疗方法提供信息的理解。