Cardiovascular diseases are a serious threat to human health, especially in the elderly. Vascular aging makes people more susceptible to cardiovascular diseases due to significant dysfunction or senescence of vascular cells and maladaptation of vascular structure and function; moreover, vascular aging is currently viewed as a modifiable cardiovascular risk factor. To emphasize the relationship between senescent cells and vascular aging, we first summarize the roles of senescent vascular cells (endothelial cells, smooth muscle cells and immune cells) in the vascular aging process and inducers that contribute to cellular senescence. Then, we present potential strategies for directly targeting senescent cells (senotherapy) or preventively targeting senescence inducers (senoprevention) to delay vascular aging and the development of age-related vascular diseases. Finally, based on recent research, we note some important questions that still need to be addressed in the future.

心血管疾病严重威胁人类健康，尤其是老年人。血管老化使人因血管细胞显着功能障碍或衰老，血管结构和功能不适应而更易患心血管疾病；此外，血管老化目前被视为一种可改变的心血管危险因素。为了强调衰老细胞与血管衰老之间的关系，我们首先总结了衰老血管细胞（内皮细胞、平滑肌细胞和免疫细胞）在血管衰老过程中的作用以及促进细胞衰老的诱导剂。然后，我们提出了直接靶向衰老细胞（senotherapy）或预防性靶向衰老诱导剂（senoprevention）的潜在策略，以延缓血管衰老和与年龄相关的血管疾病的发展。最后，根据最近的研究，我们指出了一些未来仍需解决的重要问题。